Document Detail


Pulmonary Antrum Radial-Linear Ablation for Paroxysmal Atrial Fibrillation: Interim Analysis of a Multicenter Trial.
MedLine Citation:
PMID:  23434517     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Substrate abnormality in pulmonary vein (PV) antrum plays a critical role in mechanism of atrial fibrillation (AF). The present study compares the strategy of PV antrum radial-linear (PAR) ablation to encircling PV isolation for paroxysmal AF. METHODS AND RESULTS: -A total of 86 patients with paroxysmal AF were randomly assigned to PAR ablation group or PV isolation group. The average procedure time was 161±21 min in PAR ablation group and 199±39 min in PV isolation group (P<0.01). The average fluoroscopy time was 25±5 min in PAR ablation group and 32±9 min in PV isolation group (P<0.001). At 14 (15-12) months of follow-up after single procedure, 31 of 42 (74%) patients in PAR ablation group and 22 of 44 patients (50%) in PV isolation group had no recurrence of AF off antiarrhythmic drug (AAD) (P=0.0249); and 36 of 42 patients (86%) in PAR ablation group and 26 of 44 patients (59%) in PV isolation group had no recurrence of AF with AAD (P=0.006). In addition, PAR ablation resulted in greater reduction of LA diameter than encircling PV isolation. Multivariable Cox regression analysis showed that only ablation strategy was independently associated with AF recurrence (HR, 0.31; 95% CI: 0.12-0.78; P=0.013). No major adverse event related to the procedures occurred. CONCLUSIONS: -This study suggests that PAR ablation is a potentially effective strategy for treatment of paroxysmal AF warranting further investigation. Clinical Trial Registration Information-www.chictr.org; Identifier: ChiCTR-TRC-11001191.
Authors:
Xue Zhao; Jiayou Zhang; Jianqiang Hu; Dening Liao; Yinxiang Zhu; Xiang Mei; Jun Sheng; Fang Yuan; Yanping Gui; Wenliang Lu; Li Dai; Xingui Guo; Yawei Xu; Yanzhou Zhang; Ben He; Zhenguo Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-22
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Changzheng Hospital, Second Military Medical University, Shanghai, China.
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