| Pull-out strength of multifunctional bioabsorbable ciprofloxacin-releasing polylactide-polyglycolide 80/20 tacks: an experimental study allograft cranial bone. | |
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MedLine Citation:
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PMID: 19164990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the pull-out forces of recently developed multifunctional bioabsorbable self-reinforced ciprofloxacin-releasing polylactide/polyglycolide (SR-PLGA+AB) 80/20 tacks were compared with plain SR-PLGA 80/20 tacks in human cadaver parietal bones. Pieces of parietal bone (approximately 6 x 20 cm) were harvested from 5 human cadavers (all were male, 29-77 years old). Fifty plain SR-PLGA tacks (diameter, 2.0 mm; length, 6.0 mm) and 50 ciprofloxacin-releasing SR-PLGA tacks of similar dimensions were applied to drill holes using a special tack shooter without tapping the drill holes. The force needed to pull the tacks from human parietal cadaver bones was measured using a universal tensile-testing machine, by tack pull-out speed of 10 mm/min. Means and SDs were calculated and analyzed using Student's t-test (SPSS version 10.0 for Windows). The pull-out forces of the ciprofloxacin-releasing and plain tacks were 147.0 +/- 5.94 and 141.4 +/- 8.97 N respectively (P = 0.14, statistically insignificant difference between the 2 groups). The cause of failure in all cases was barb breakage. Ciprofloxacin-releasing SR-PLGA 80/20 tacks seem to have a similar holding power to cranial bone as plain SR-PLGA (80/20) tacks but have additional advantage of ciprofloxacin release. |
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Authors:
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Johanna Tiainen; Kaisa Knuutila; Minna Veiranto; Esa Suokas; Pertti Törmälä; Outi Kaarela; Satu Länsman; Nureddin Ashammakhi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of craniofacial surgery Volume: 20 ISSN: 1536-3732 ISO Abbreviation: J Craniofac Surg Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010410 Medline TA: J Craniofac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 58-61 Citation Subset: D |
Affiliation:
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Department of Surgery, Oulu University Hospital, Oulu, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Adult Aged Anti-Infective Agents / chemistry* Biocompatible Materials / chemistry* Bone Nails* Cadaver Ciprofloxacin / chemistry* Diffusion Equipment Design Humans Lactic Acid / chemistry* Male Materials Testing Microscopy, Electron, Scanning Middle Aged Parietal Bone / surgery* Polyglycolic Acid / chemistry* Stress, Mechanical Surface Properties Tensile Strength |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Biocompatible Materials; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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