Document Detail

Published genetic variants in retinopathy of prematurity: random forest analysis suggests a negligible contribution to risk and severity.
MedLine Citation:
PMID:  18568888     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Our recent investigations suggested association between severe retinopathy of prematurity (ROP) and some genetic polymorphisms contributing to angiogenesis. While these findings may help to identify specific elements in ROP pathogenesis, the predictive value of these genetic variants at birth is unknown. We applied a high-dimensional nonparametric method called random forest technique (RFT) to evaluate the predictive value of genetic polymorphisms in ROP at birth. METHODS: We used published genetic (i.e., VEGF T(-460)C, G(+ 405)C, and C(-2578)A; IGF-I receptor G(+ 3174)A, angiopoietin II G(-35)C; estrogen receptor PvuII Pp; and endothelial NO-synthase 27-bp b/a and T(-786)C) and birth data of 134 preterm infants without and 103 preterm infants with ROP requiring laser or cryotherapy. We used RFT to determine the relative importance scores (IS) of each clinical parameter at birth and genetic polymorphisms in the prediction of ROP. The accuracy of ROP prediction at birth was calculated when birth data, genotype data, and birth data PLUS genotype data were taken into account. RESULTS: The most important predictors of ROP were prematurity, low birth weight, intrauterine retardation, and Apgar scores with IS values between 7.46 and 13.20. IS values of genotype data were much lower in the range between 0.86 and 4.19. When birth data solely, genotype data solely, and birth data plus genotype data together were used for prediction, the accuracy of prediction was 0.653, 0.636, and 0.674, respectively. CONCLUSIONS: The tested genetic polymorphisms (including those published as significant risk factors of ROP) are not good predictors of ROP at birth.
György Dunai; Barna Vásárhelyi; Miklós Szabó; Júlia Hajdú; Gergõ Mészáros; Tivadar Tulassay; András Treszl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  33     ISSN:  1460-2202     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-07-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-5     Citation Subset:  IM    
Csolnoky Ferenc Hospital, Veszprem, Hungary.
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MeSH Terms
Angiopoietin-2 / genetics
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Nitric Oxide Synthase Type III / genetics
Polymorphism, Genetic*
Receptor, IGF Type 1 / genetics
Receptors, Estrogen / genetics
Retinopathy of Prematurity / genetics*
Risk Factors
Severity of Illness Index
Statistics, Nonparametric*
Vascular Endothelial Growth Factor A / genetics
Reg. No./Substance:
0/Angiopoietin-2; 0/Receptors, Estrogen; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; EC protein, human; EC Oxide Synthase Type III; EC, IGF Type 1

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