| Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. | |
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MedLine Citation:
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PMID: 18482434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During puberty, neuronal maturation of the brain, which began during perinatal development, is completed such that the behavioral potential of the adult organism can be fully achieved. These maturational events and processes of reorganization are needed for the occurrence of adult behavioral performance but simultaneously render the organism highly susceptible to perturbations, such as exposure to psychoactive drugs, during this critical developmental time span. Considering the variety of maturational processes occurring in the endocannabinoid system during this critical period, it is not surprising that the still-developing brain might by highly susceptible to cannabis exposure. Emerging evidence from human studies and animal research demonstrates that an early onset of cannabis consumption might have lasting consequences on cognition, might increase the risk for neuropsychiatric disorders, promote further illegal drug intake and increase the likelihood of cannabis dependence. These findings suggest that young people represent a highly vulnerable cannabis consumer group and that they run a higher risk than adult consumers of suffering from adverse consequences from cannabinoid exposure. The aim of the present review is to provide an overview over the possible deleterious residual cannabinoid effects during critical periods of postnatal maturation and to offer a more precise delineation of the vulnerable time window for cannabinoid exposure. |
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Authors:
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Miriam Schneider |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Addiction biology Volume: 13 ISSN: 1369-1600 ISO Abbreviation: Addict Biol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-16 Completed Date: 2008-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604935 Medline TA: Addict Biol Country: England |
Other Details:
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Languages: eng Pagination: 253-63 Citation Subset: IM |
Affiliation:
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Central Institute of Mental Health (ZI), Department of Psychopharmacology, Mannheim, Germany. miriam.schneider@zi-mannheim.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Brain / drug effects*, physiopathology Cannabinoids / toxicity* Child Cognition Disorders / chemically induced*, physiopathology, psychology Drug Tolerance Endocannabinoids / metabolism* Humans Marijuana Abuse / physiopathology*, psychology Neurons / drug effects, physiology Neuropsychological Tests Psychoses, Substance-Induced / physiopathology*, psychology Puberty / drug effects*, physiology* Receptor, Cannabinoid, CB1 / drug effects*, physiology* Risk Factors Substance-Related Disorders / physiopathology, psychology Tetrahydrocannabinol / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Cannabinoids; 0/Endocannabinoids; 0/Receptor, Cannabinoid, CB1; 1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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