| Pubertal development in daughters of women with pre-eclampsia. | |
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MedLine Citation:
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PMID: 20930013 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective To compare clinical signs of puberty onset in daughters of pre-eclampsia and normotensive pregnancies. Design Population based follow-up study. Methods In a cohort of 120 daughters of pre-eclampsia pregnancies and 203 daughters of pregnancies without pre-eclampsia, pubic hair growth and breast development were assessed at 11, 12 and 13 years of age by Tanner scores and by self-assessment. Results Compared to the normotensive group, pubic hair growth (pubarche) more often preceded breast development (thelarche) (risk ratio (RR) 2.3, 95% CI 1.3 to 4.1) and thelarche less often preceded pubarche (RR 0.8, 95% CI 0.7 to 1.0) in daughters of pre-eclampsia pregnancies. Adjustment for birth weight and body mass index in early adolescence did not substantially influence these results, but increasing severity of pre-eclampsia strengthened the differences. Conclusions Pubarche tends to precede thelarche in daughters of pre-eclampsia pregnancies compared to daughters of normotensive pregnancies. This may reflect a stronger androgenic influence in daughters of pre-eclampsia pregnancies at the beginning of puberty. |
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Authors:
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Bjorn Ogland; Stein T Nilsen; Michele R Forman; Lars J Vatten |
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Publication Detail:
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Type: Journal Article Date: 2010-10-07 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 96 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 740-3 Citation Subset: AIM; IM |
Affiliation:
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Neonatal Intensive Care Unit, Rikshospitalet-Radiumhospitalet Medical Center, Gunnar Schelderupsvei 11d, 0485 Oslo, Norway; bogland@online.no. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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