Document Detail

Pubertal development in daughters of women with pre-eclampsia.
MedLine Citation:
PMID:  20930013     Owner:  NLM     Status:  In-Data-Review    
Objective To compare clinical signs of puberty onset in daughters of pre-eclampsia and normotensive pregnancies. Design Population based follow-up study. Methods In a cohort of 120 daughters of pre-eclampsia pregnancies and 203 daughters of pregnancies without pre-eclampsia, pubic hair growth and breast development were assessed at 11, 12 and 13 years of age by Tanner scores and by self-assessment. Results Compared to the normotensive group, pubic hair growth (pubarche) more often preceded breast development (thelarche) (risk ratio (RR) 2.3, 95% CI 1.3 to 4.1) and thelarche less often preceded pubarche (RR 0.8, 95% CI 0.7 to 1.0) in daughters of pre-eclampsia pregnancies. Adjustment for birth weight and body mass index in early adolescence did not substantially influence these results, but increasing severity of pre-eclampsia strengthened the differences. Conclusions Pubarche tends to precede thelarche in daughters of pre-eclampsia pregnancies compared to daughters of normotensive pregnancies. This may reflect a stronger androgenic influence in daughters of pre-eclampsia pregnancies at the beginning of puberty.
Bjorn Ogland; Stein T Nilsen; Michele R Forman; Lars J Vatten
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Publication Detail:
Type:  Journal Article     Date:  2010-10-07
Journal Detail:
Title:  Archives of disease in childhood     Volume:  96     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  740-3     Citation Subset:  AIM; IM    
Neonatal Intensive Care Unit, Rikshospitalet-Radiumhospitalet Medical Center, Gunnar Schelderupsvei 11d, 0485 Oslo, Norway;
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