| Pubertal changes of insulin sensitivity, acute insulin response, and β-cell function in overweight Latino youth. | |
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MedLine Citation:
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PMID: 20888012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and β-cell function/disposition index (DI) across puberty in overweight Latino boys and girls. STUDY DESIGN: Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Tanner stage. RESULTS: In boys, SI decreased in early puberty with a recovery by late puberty. The compensatory increase in AIR was appropriate in early maturation, but after Tanner stage 3, AIR declined by more than that predicted from the recovery in SI. For girls, SI decreased in early puberty and across all stages of maturation. In early maturation, there was an appropriate compensatory increase in AIR, but after Tanner stage 3, AIR decreased. Thus, DI deteriorated across puberty in boys and girls. CONCLUSIONS: In overweight Hispanic youth, compensatory changes in insulin secretion fails after Tanner stage 3 in both sexes, indicating β-cell deterioration during this critical period of development, thus increasing risk for type 2 diabetes. |
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Authors:
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Louise A Kelly; Christianne J Lane; Marc J Weigensberg; Claudia M Toledo-Corral; Michael I Goran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-04-05 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 442-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Exercise Science, California Lutheran University, Los Angeles, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Female Hispanic Americans* Humans Insulin / metabolism* Insulin Resistance / ethnology* Insulin-Secreting Cells / secretion* Longitudinal Studies Los Angeles / epidemiology Male Overweight / ethnology*, metabolism Puberty* Regression Analysis Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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F31-DK081276/DK/NIDDK NIH HHS; M01 RR 00043/RR/NCRR NIH HHS; M01 RR000043-440882/RR/NCRR NIH HHS; R01 DK 59211/DK/NIDDK NIH HHS; R01 DK059211-01/DK/NIDDK NIH HHS; R01 DK059211-12/DK/NIDDK NIH HHS; U54 CA 116848/CA/NCI NIH HHS; U54 CA116848-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin |
| Comments/Corrections | |
Erratum In:
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J Pediatr. 2011 Nov;159(5):878 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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