| Pubarche induction with testosterone treatment in women with panhypopituitarism. | |
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MedLine Citation:
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PMID: 8566275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy and safety of T therapy in the induction of pubic hair growth in women with congenital panhypopituitarism. DESIGN: Prospective clinical study. SETTING: Patients followed at the University Endocrinology Clinic. PATIENTS: Four women with congenital panhypopituitarism, showing no pubic hair development, currently treated with substitutive therapy with L-thyroxine, cortisone acetate, and estrogen-progestin combination. INTERVENTIONS: A long-acting T preparation (25 to 50 mg) was given IM each month; serum T levels were determined before and after 12 and 24 months of therapy. MAIN OUTCOME MEASURE: Evaluation of pubarche stages (according to Tanner classification of stages). RESULTS: Patients developed pubarche (Tanner stage 3 to 5) after 3 to 18 months of T therapy. Testosterone levels were within the normal range during treatment. No hirsutism or other side effects were recorded. CONCLUSION: A cautious T treatment represents an effective and safe approach to the problem of pubarche induction in women with congenital panhypopituitarism. |
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Authors:
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G Padova; C Finocchiaro; G Briguglia; A Magro; P Tita; V Pezzino |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 65 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-03-04 Completed Date: 1996-03-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 437-9 Citation Subset: IM |
Affiliation:
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Università di Catania, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Hair Humans Hypopituitarism / complications, congenital, drug therapy* Prospective Studies Puberty, Delayed / drug therapy*, etiology Testosterone / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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