Document Detail

Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities.
MedLine Citation:
PMID:  9186558     Owner:  NLM     Status:  MEDLINE    
Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
M Engler; T Anke; O Sterner; U Brandt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  50     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
LB Biotechnologie der Universität, Kaiserslautern, FRG.
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MeSH Terms
Acetic Acids / isolation & purification*,  pharmacology*
Antifungal Agents / isolation & purification*,  pharmacology*
Benzofurans / isolation & purification*,  pharmacology*
Chromatography, High Pressure Liquid
Electron Transport Complex I
Microbial Sensitivity Tests
Mitochondria / drug effects
NADH, NADPH Oxidoreductases / antagonists & inhibitors*
Oxygen Consumption
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/Acetic Acids; 0/Antifungal Agents; 0/Benzofurans; 0/Oxepins; 0/pterulinic acid; 0/pterulone; EC 1.6.-/NADH, NADPH Oxidoreductases; EC Transport Complex I

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