| Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities. | |
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MedLine Citation:
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PMID: 9186558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I). |
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Authors:
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M Engler; T Anke; O Sterner; U Brandt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antibiotics Volume: 50 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-24 Completed Date: 1997-07-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 325-9 Citation Subset: IM |
Affiliation:
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LB Biotechnologie der Universität, Kaiserslautern, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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isolation & purification*,
pharmacology* Animals Antifungal Agents / isolation & purification*, pharmacology* Benzofurans / isolation & purification*, pharmacology* Cattle Chromatography, High Pressure Liquid Electron Transport Complex I Fermentation Microbial Sensitivity Tests Mitochondria / drug effects NADH, NADPH Oxidoreductases / antagonists & inhibitors* Oxepins* Oxygen Consumption Stereoisomerism Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Antifungal Agents; 0/Benzofurans; 0/Oxepins; 0/pterulinic acid; 0/pterulone; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.5.3/Electron Transport Complex I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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