Document Detail

Pterin metabolism in depression: an extension of the amine hypothesis and possible marker of response to ECT.
MedLine Citation:
PMID:  1488484     Owner:  NLM     Status:  MEDLINE    
Urinary excretion of neopterins and biopterins was measured in 23 patients with severe depression before and after receiving electroconvulsive therapy (ECT) and 26 healthy control subjects. Patients with psychotic depression and those responding to ECT had neopterin:biopterin (N:B) ratio significantly higher than controls before commencing ECT and positive therapeutic response was associated with reduction of N:B ratio towards control values. As a raised N:B ratio implies failure to convert neopterin to biopterin it is possible that reduced availability of tetrahydrobiopterin, the essential cofactor for the formation of noradrenaline, serotonin and dopamine, may exert rate limiting control over the synthesis of monoamines implicated in the pathogenesis of depressive disorders. The N:B ratio may be a marker for certain depressive subtypes and response to ECT.
D N Anderson; M T Abou-Saleh; J Collins; K Hughes; R J Cattell; C G Hamon; J A Blair; M E Dewey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychological medicine     Volume:  22     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  IM    
Department of Psychiatry, Fazakerley Hospital, Liverpool.
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MeSH Terms
Biological Markers
Depressive Disorder / diagnosis,  metabolism*,  therapy
Electroconvulsive Therapy*
Middle Aged
Psychiatric Status Rating Scales
Psychotropic Drugs / classification,  therapeutic use
Pterins / analysis,  metabolism*,  urine
Urine / chemistry
Reg. No./Substance:
0/Biological Markers; 0/Psychotropic Drugs; 0/Pterins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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