| Psychotropic medication exposure and age at onset of bipolar disorder in offspring of parents with bipolar disorder. | |
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MedLine Citation:
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PMID: 20166793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Exposure to psychotropic medications before the onset of bipolar disorder (BD) in children may have profound effects on the course of illness. Both antidepressant and stimulant exposure have been proposed to hasten the course of BD development, whereas mood stabilizers have been proposed as protective. We sought to describe psychotropic medication exposure in a cohort of children at risk for BD and retrospectively determine the effect of medication exposure on age at onset (AAO) of BD. METHODS: Subjects were 106 children and adolescents who had at least 1 parent with BD. Of these, 63 had BD I or BD II and 43 had subsyndromal symptoms of BD. AAO was determined as nearest month of first manic or hypomanic episode. Past psychotropic medication exposure prior to AAO was determined through interview and chart review. RESULTS: Both groups had high rates of exposure to psychotropic medications. Antidepressant or stimulant exposure was not correlated with an earlier AAO of BD. However, mood stabilizer exposure was associated with a later AAO. CONCLUSIONS: Children with full or subsyndromal BD are frequently exposed to a variety of psychotropic medications before their first manic episode. Our findings do not support that early stimulant or antidepressant exposure leads to an earlier AAO of BD. However, early mood stabilizer exposure may be associated with delayed AAO. Longitudinal studies are needed to clarify these results. |
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Authors:
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Kiki D Chang; Kirti Saxena; Meghan Howe; Diana Simeonova |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child and adolescent psychopharmacology Volume: 20 ISSN: 1557-8992 ISO Abbreviation: J Child Adolesc Psychopharmacol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-05-19 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9105358 Medline TA: J Child Adolesc Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 25-32 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305-5540, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Age of Onset Bipolar Disorder / diagnosis, drug therapy*, epidemiology*, genetics California Child Child of Impaired Parents / psychology* Cohort Studies Family Health* Female Genetic Predisposition to Disease Humans Male Parent-Child Relations Parents Psychiatric Status Rating Scales Psychotropic Drugs* / therapeutic use Retrospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH077047-05/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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