Document Detail

Psychotropic drugs in breast milk: no evidence for adverse effects on prepulse modulation of startle reflex or on cognitive level in infants.
MedLine Citation:
PMID:  9553734     Owner:  NLM     Status:  MEDLINE    
Reversals in modulation of the startle reflex probably reflect maturational processes in the central nervous system. This study has investigated the longitudinal changes in prepulse modulation of the blink reflex in three groups of individual infants: (a) breast-fed infants of mentally ill mothers who were prescribed selected psychotropic drugs, (b) bottle-fed infants of similarly ill and medicated mothers, and (c) breast-fed infants of healthy control mothers. The acoustic stimulation paradigm and neurophysiological methods were similar to those used in previous studies and, in addition, the infants' development was simultaneously assessed using the Bayley Scales of Infant Development. All the infants were found to be developing normally and across all three groups we observed a clear transition in prepulse modulation of the eye-blink reflex from small inhibition or facilitation in early infancy (1-4 months) to a robust facilitation in middle infancy (5-8 months). This reversal probably reflects the changing balance of developing neural function in normal infants. There were, therefore, no discernible effects in breast-fed infants of exposure to small doses of antidepressant or neuroleptic drugs.
K Yoshida; R C Kumar; B Smith; M Craggs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  32     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-13     Completed Date:  1998-07-13     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
Section of Perinatal Psychiatry, Institute of Psychiatry, London, UK.
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MeSH Terms
Acoustic Stimulation
Age Factors
Analysis of Variance
Arousal / drug effects,  physiology
Blinking / drug effects,  physiology
Breast Feeding / adverse effects*
Case-Control Studies
Central Nervous System / drug effects*,  growth & development
Child Development*
Cognition / drug effects
Developmental Disabilities / chemically induced*
Longitudinal Studies
Maternal Exposure*
Motor Skills / drug effects
Neural Inhibition / drug effects,  physiology
Psychotropic Drugs / adverse effects*
Reaction Time / drug effects,  physiology
Startle Reaction / drug effects*,  physiology
Time and Motion Studies
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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