| Psychotropic drugs in breast milk: no evidence for adverse effects on prepulse modulation of startle reflex or on cognitive level in infants. | |
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MedLine Citation:
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PMID: 9553734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reversals in modulation of the startle reflex probably reflect maturational processes in the central nervous system. This study has investigated the longitudinal changes in prepulse modulation of the blink reflex in three groups of individual infants: (a) breast-fed infants of mentally ill mothers who were prescribed selected psychotropic drugs, (b) bottle-fed infants of similarly ill and medicated mothers, and (c) breast-fed infants of healthy control mothers. The acoustic stimulation paradigm and neurophysiological methods were similar to those used in previous studies and, in addition, the infants' development was simultaneously assessed using the Bayley Scales of Infant Development. All the infants were found to be developing normally and across all three groups we observed a clear transition in prepulse modulation of the eye-blink reflex from small inhibition or facilitation in early infancy (1-4 months) to a robust facilitation in middle infancy (5-8 months). This reversal probably reflects the changing balance of developing neural function in normal infants. There were, therefore, no discernible effects in breast-fed infants of exposure to small doses of antidepressant or neuroleptic drugs. |
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Authors:
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K Yoshida; R C Kumar; B Smith; M Craggs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental psychobiology Volume: 32 ISSN: 0012-1630 ISO Abbreviation: Dev Psychobiol Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-13 Completed Date: 1998-07-13 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 249-56 Citation Subset: IM |
Affiliation:
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Section of Perinatal Psychiatry, Institute of Psychiatry, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Age Factors Analysis of Variance Arousal / drug effects, physiology Blinking / drug effects, physiology Breast Feeding / adverse effects* Case-Control Studies Central Nervous System / drug effects*, growth & development Child Development* Cognition / drug effects Developmental Disabilities / chemically induced* Female Humans Infant Longitudinal Studies Maternal Exposure* Motor Skills / drug effects Neural Inhibition / drug effects, physiology Psychotropic Drugs / adverse effects* Reaction Time / drug effects, physiology Startle Reaction / drug effects*, physiology Time and Motion Studies |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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