Document Detail


Psychotropic drugs as behavioral teratogens.
MedLine Citation:
PMID:  472738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.
Authors:
C V Vorhees; R L Brunner; R E Butcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  205     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1220-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Brain Chemistry / drug effects
Dextropropoxyphene / pharmacology*
Disease Models, Animal*
Female
Fenfluramine / pharmacology*
Humans
Litter Size / drug effects
Male
Movement Disorders / chemically induced
Pregnancy
Pregnancy, Animal / drug effects*
Prochlorperazine / pharmacology*
Rats
Reproduction / drug effects
Sex Ratio / drug effects
Swimming
Chemical
Reg. No./Substance:
458-24-2/Fenfluramine; 469-62-5/Dextropropoxyphene; 58-38-8/Prochlorperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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