Document Detail

Psychotropic drug use in pregnancy and perinatal death.
MedLine Citation:
PMID:  1356291     Owner:  NLM     Status:  MEDLINE    
The psychotropic drug use in mothers to all 73 perinatally dead infants in the city of Gothenburg, Sweden, in 1985-86, was compared to a control group of mothers to 73 surviving infants. Information regarding medication in pregnancy and pre- and perinatal data was collected retrospectively. In addition, serum samples obtained in early pregnancy were screened for benzodiazepines. Eighteen case-mothers used psychotropic drugs during pregnancy compared with 7 control-mothers. The association between psychotropic drug use and perinatal death was significant (p = 0.01). Psychotropic drug use and maternal disorder were closely correlated, but within the case group there were no significant differences between mothers using or not using psychotropic drugs in terms of age, parity or smoking habits. Although the etiology of death could be discussed in the individual infant, we find it noteworthy that the use of psychotropic drugs was so frequent in the mothers of perinatally dead infants.
L Laegreid; N Conradi; G Hagberg; T Hedner
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  71     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  451-7     Citation Subset:  IM    
Department of Pediatrics II, University of Göteborg, Sweden.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Anti-Anxiety Agents / adverse effects,  therapeutic use
Fetal Death / chemically induced*
Infant Mortality*
Infant, Newborn
Pregnancy Complications / drug therapy
Psychotropic Drugs / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Psychotropic Drugs; 12794-10-4/Benzodiazepines
Comment In:
Acta Obstet Gynecol Scand. 1992 Aug;71(6):492-3   [PMID:  1326851 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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