Document Detail

Psychotic symptoms and gray matter deficits in clinical pediatric populations.
MedLine Citation:
PMID:  22835806     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neuroanatomic studies have not yet addressed how subtle phenotypic distinctions in psychosis alter the underlying brain changes, and whether there is evidence for psychosis as a dimensional construct. We explored the relationship of cortical GM thickness to psychotic phenotypes in children.
METHODS: Cross-sectional comparison of anatomic brain imaging between patients referred as childhood-onset schizophrenia (COS) but ruled out after a drug free inpatient observation. Groups included: patients with no evidence of psychosis (n=22) after drug free observation, patients with psychosis not otherwise specified (PNOS; total n=29) further divided into those without other axis I diagnoses (n=13) and those with other axis I comorbidities (n=16), age/sex matched COS patients (n=48), and 51 matched healthy controls. GM cortical thickness was compared between the groups, and regressed on patients' SAPS, SANS and GAS scores.
RESULTS: Patients with no evidence of psychosis showed no cortical GM deficits. Presence of psychosis (PNOS with or without co-morbidities) showed some areas of temporal and prefrontal deficits, more subtle compared to the extensive bilateral cortical deficits seen for COS. GAS SAPS and SANS scores showed a relationship with cortical GM thickness although it did not survive adjustment for multiple comparisons.
CONCLUSIONS: These results highlight the need for careful phenotypic characterization, as subtle diagnostic distinctions appear to reflect distinct underlying patterns of brain deficits. The incremental nature of cortical deficits from no psychosis to PNOS to COS may further support dimensional model for psychosis.
Nitin Gogtay; Brian Weisinger; Jennifer L Bakalar; Reva Stidd; Oscar Fernandez de la Vega; Rachel Miller; Liv Clasen; Deanna Greenstein; Judith L Rapoport
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2012-07-24
Journal Detail:
Title:  Schizophrenia research     Volume:  140     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-18     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Child Psychiatry Branch, National Institutes of Health, Building 10, Center Dr., Bethesda, MD 20892, USA.
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MeSH Terms
Analysis of Variance
Brain / pathology
Case-Control Studies
Cross-Sectional Studies
Image Processing, Computer-Assisted
Leukoencephalopathies / epidemiology*,  pathology*
Magnetic Resonance Imaging
Retrospective Studies
Schizophrenia, Childhood / epidemiology*,  pathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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