Document Detail


Psychostimulants induce low-frequency oscillations in the firing activity of dopamine neurons.
MedLine Citation:
PMID:  15257309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reinforcing properties of psychostimulants depend critically on their effects on dopamine (DA) neurons in the ventral tegmental area (VTA). Using in vivo single unit recording in rats and spectral analysis, this study presents evidence for a new, non-DA-mediated effect of psychostimulants on VTA DA neurons. Thus, as previously observed with D-amphetamine, all psychostimulants tested, including cocaine, methamphetamine, and methylphenidate, had two opposing effects on firing rate of DA neurons: a DA-mediated inhibition and a non-DA-mediated excitation. The latter effect was normally masked by the DA-mediated inhibition and was revealed when the inhibition was blocked by a DA antagonist. Using spectral analysis, this study further showed that during psychostimulant-induced excitation, DA cells exhibited not only an increase in firing rate and bursting but also a low-frequency rhythmic oscillation (0.5-1.5 Hz) in their firing activity. The oscillatory response was unique to psychostimulants since it was not observed with the GABA(A) agonist muscimol, which also increased DA cell firing, and not mimicked by the nonpsychostimulant DA agonist L-dopa. Results further suggest that the effect requires activation of adrenergic alpha1 receptors and depends on intact forebrain inputs to DA neurons. Further understanding of this novel effect may provide important insights into both the mechanism of action of psychostimulants and the neuronal circuitry that controls the activity of DA neurons in the brain.
Authors:
Wei-Xing Shi; Chen-Lun Pun; Yan Zhou
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  29     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-02-14     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2160-7     Citation Subset:  IM    
Affiliation:
Neuropsychopharmacological Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. wei-xing.shi@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects*
Animals
Central Nervous System Stimulants / pharmacology*
Dopamine / metabolism*
Dopamine Agents / pharmacology
Drug Interactions
Functional Laterality / physiology
GABA Agonists / pharmacology
Male
Muscimol / pharmacology
Neurons / drug effects*
Periodicity*
Prosencephalon / physiology
Rats
Rats, Sprague-Dawley
Spectrum Analysis / methods
Ventral Tegmental Area / cytology
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Dopamine Agents; 0/GABA Agonists; 2763-96-4/Muscimol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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