Document Detail


Psychosocial stress and chronic ethanol ingestion in male rats: effects on elevated plus maze behavior and ultrasonic vocalizations.
MedLine Citation:
PMID:  18417174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psychosocial stress is known to enhance anxiety levels in rodents. The present study evaluated the effect of long-term ingestion of ethanol (EtOH) on anxiety levels of male Long Evans rats housed either singly or in triads (three/cage). Based on measures of offensive and defensive behaviors, triad-housed rats were designated as being dominant, subdominant or subordinate. The effect of chronic ingestion of a 6% EtOH solution was assessed on behaviors in the elevated plus maze (EPM) test, and on air-puffs elicited 22 kHz ultrasonic vocalizations (USV). EtOH naïve dominant rats showed less anxiogenic-like (open arms time) and displacement behavior (grooming), but more risk assessment behavior (stretch-attend postures) than their cage-mates or the single-housed rats. Intake of EtOH prior to the EPM test was lower in dominant and single-housed rats compared to subdominant and subordinate rats. Triad-housed rats, but not the single-housed rats, decreased their intake of EtOH after the EPM test. Overall, EtOH intake had an anxiolytic effect in all rats, but the effect was most prominent in single-housed rats. Furthermore, EtOH intake decreased air-puff induced USVs of triad-housed rats, but increased USVs of single-housed rats. These data indicate that housing condition and rank status influence the emotional state of male rats. Furthermore, the anxiolytic effect of voluntarily ingested EtOH was depended on these variables.
Authors:
Larissa A Pohorecky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-04
Journal Detail:
Title:  Physiology & behavior     Volume:  94     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-20     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-47     Citation Subset:  IM    
Affiliation:
Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, NJ 08854-1100, USA. larissa@rci.rutgers.edu
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MeSH Terms
Descriptor/Qualifier:
Agonistic Behavior / drug effects,  physiology
Alcohol Drinking / physiopathology*,  psychology
Analysis of Variance
Animals
Behavior, Animal
Central Nervous System Depressants / administration & dosage*
Ethanol / administration & dosage*
Hierarchy, Social
Male
Maze Learning / drug effects*,  physiology
Posture
Rats
Rats, Long-Evans
Stress, Psychological / physiopathology*
Vocalization, Animal / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
AAA10124//PHS HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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