| Psychosocial influences on immune responses to HSV-1 infection in BALB/c mice. | |
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MedLine Citation:
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PMID: 9193767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of differential housing (one or four mice/cage) on T-helper (Th) cell markers of cellular and humoral immune responses were examined. Differentially housed male BALB/cJ mice were infected with herpes simplex virus (HSV)-1 (Patton strain), and in vitro cytokine production [interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-gamma] by splenocytes and popliteal lymph node cells and serum antibody titers (IgM and IgG) were evaluated. Differential housing of male BALB/c mice influenced the magnitude, but not the kinetics, of some, but not all, immune responses to HSV-1. Splenocytes from individually housed mice produced more IL-2, IFN-gamma, IL-4, and IL-10 than splenocytes from group-housed mice; in popliteal lymph node cells, only IFN-gamma and IL-10 production was influenced by housing. Although the social environment influenced cytokine production, there were no concomitant changes in circulating IgM or IgG antibody titers. These results do not support the hypothesis that dominant Th cell responses are the primary targets of this psychosocial manipulation, or that a reciprocal relationship exists between Th1 and Th2 cell-derived cytokines. |
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Authors:
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J D Karp; J A Moynihan; R Ader |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 11 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-09-05 Completed Date: 1997-09-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 47-62 Citation Subset: IM |
Affiliation:
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Center for Psychoneuroimmunology Research, University of Rochester Medical Center, New York 14642, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / metabolism* Herpesvirus 1, Human / immunology* Male Mice Mice, Inbred BALB C Social Behavior* T-Lymphocytes / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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