| Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B). | |
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MedLine Citation:
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PMID: 21511440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics at the University of California, San Francisco and UC Los Angeles completed the PQ-B and the Structured Interview for Prodromal Syndromes (SIPS) at intake. Endorsement of three or more positive symptoms on the PQ-B differentiated between those with prodromal syndrome and psychotic syndrome diagnoses on the SIPS versus those with no SIPS diagnoses with 89% sensitivity, 58% specificity, and a positive Likelihood Ratio of 2.12. A Distress Score measuring the distress or impairment associated with endorsed positive symptoms increased the specificity to 68%, while retaining similar sensitivity of 88%. Agreement was very similar when participants with psychotic syndromes were excluded from the analyses. These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations. |
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Authors:
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Rachel L Loewy; Rahel Pearson; Sophia Vinogradov; Carrie E Bearden; Tyrone D Cannon |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Validation Studies Date: 2011-04-20 |
Journal Detail:
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Title: Schizophrenia research Volume: 129 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-12-06 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 42-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143-0984, United States. RLoewy@Lppi.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Male Mass Screening / methods* Predictive Value of Tests Psychiatric Status Rating Scales / standards* Psychotic Disorders / diagnosis* Questionnaires / standards* Reproducibility of Results Schizophrenia / diagnosis* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K23 MH086618-01/MH/NIMH NIH HHS; K23 MH086618-02/MH/NIMH NIH HHS; K23 MH086618-03/MH/NIMH NIH HHS; K23 MH086618-04/MH/NIMH NIH HHS; K23MH086618/MH/NIMH NIH HHS; L30 MH081718-01/MH/NIMH NIH HHS; L30 MH081718-02/MH/NIMH NIH HHS; L30 MH081718-03/MH/NIMH NIH HHS; MH65079/MH/NIMH NIH HHS; P50 MH066286/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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