Document Detail

Psychophysiological measures of (dis)inhibition as liability indicators for schizophrenia.
MedLine Citation:
PMID:  9844427     Owner:  NLM     Status:  MEDLINE    
Two psychophysiological measures, poor suppression of midlatency auditory-evoked responses in a paired stimulus paradigm and ocular motor abnormalities, may index genetic liability for schizophrenia. An important feature of these measures is that both patients and their nonpsychotic relatives exhibit basically the same performance. These measures may be successful endophenotypes for schizophrenia because they assess poor response inhibition associated with dysfunction of dorsolateral prefrontal cortex circuitry. Data bearing on this hypothesis are reviewed, and it is posited that assessment of the auditory-evoked gamma band response and saccade measures of inhibitory abilities are the most valid behavioral measures of schizophrenia's neuropathological correlates. The extant data suggest that psychophysiological studies of schizophrenia can provide consistent and theoretically meaningful information for localizing neuropathology and for assessing the genetics of this complex disorder.
B A Clementz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Psychophysiology     Volume:  35     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  648-68     Citation Subset:  IM    
Department of Psychology, University of California-San Diego 92093-0109, USA.
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MeSH Terms
Evoked Potentials, Auditory / genetics,  physiology
Genetic Predisposition to Disease / genetics*
Neural Inhibition / genetics*,  physiology
Pursuit, Smooth / genetics,  physiology
Reaction Time / genetics,  physiology
Schizophrenia / diagnosis,  genetics*,  physiopathology
Grant Support

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