Document Detail

Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder.
MedLine Citation:
PMID:  10715357     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of this study was to evaluate the acquisition, generalization, and extinction of conditioned physiologic responses to aversive stimuli in posttraumatic stress disorder (PTSD). METHODS: Thirty-six PTSD patients, 20 individuals with past trauma and no current PTSD, and 30 mentally healthy individuals without exposure to major trauma underwent a differential aversive conditioning experiment. Bursts of 105 dB white noise were used as unconditioned stimuli (UCSs), and 35x24 mm slides of different colors served as either CS+ (paired) or CS- (unpaired) stimuli. Heart rate (HR) and nondominant palm skin conductance (SC) were measured at rest and between 1 and 4 sec following each CS presentation. RESULTS: The PTSD group showed higher levels of resting SC and resting HR, larger SC responses to the initial presentation of unpaired CSs, larger HR responses following paired CS+ stimuli, larger SC responses to unpaired CS- during acquisition and extinction, and larger SC and HR responses to CS+ during extinction. The group differences in responses to CS+ during extinction remained statistically significant after controlling for age, resting physiologic levels, and initial responsivity. CONCLUSIONS: PTSD is associated with elevated autonomic responses to both innocuous and aversive stimuli, with larger responses to unpaired cues and with reduced extinction of conditioned responses.
T Peri; G Ben-Shakhar; S P Orr; A Y Shalev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  47     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-9     Citation Subset:  IM    
Center for Traumatic Stress, Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Aversive Therapy / methods*
Chronic Disease
Conditioning, Classical*
Extinction, Psychological
Galvanic Skin Response / physiology
Generalization (Psychology)
Heart Rate / physiology
Psychometrics / statistics & numerical data
Stress Disorders, Post-Traumatic* / diagnosis,  psychology,  therapy
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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