Document Detail


Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder.
MedLine Citation:
PMID:  10715357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The objective of this study was to evaluate the acquisition, generalization, and extinction of conditioned physiologic responses to aversive stimuli in posttraumatic stress disorder (PTSD). METHODS: Thirty-six PTSD patients, 20 individuals with past trauma and no current PTSD, and 30 mentally healthy individuals without exposure to major trauma underwent a differential aversive conditioning experiment. Bursts of 105 dB white noise were used as unconditioned stimuli (UCSs), and 35x24 mm slides of different colors served as either CS+ (paired) or CS- (unpaired) stimuli. Heart rate (HR) and nondominant palm skin conductance (SC) were measured at rest and between 1 and 4 sec following each CS presentation. RESULTS: The PTSD group showed higher levels of resting SC and resting HR, larger SC responses to the initial presentation of unpaired CSs, larger HR responses following paired CS+ stimuli, larger SC responses to unpaired CS- during acquisition and extinction, and larger SC and HR responses to CS+ during extinction. The group differences in responses to CS+ during extinction remained statistically significant after controlling for age, resting physiologic levels, and initial responsivity. CONCLUSIONS: PTSD is associated with elevated autonomic responses to both innocuous and aversive stimuli, with larger responses to unpaired cues and with reduced extinction of conditioned responses.
Authors:
T Peri; G Ben-Shakhar; S P Orr; A Y Shalev
Related Documents :
21912287 - Effects of carbohydrate supplementation on force output and time to exhaustion during s...
8820897 - The use of ratings of perceived exertion for regulating exercise levels in rowing ergom...
22240367 - "studying the cutaneous microcirculatory response during upper-limb exercise in healthy...
14751947 - Effect of ultramarathon cycling on the heart rate in elite cyclists.
10629977 - The maximum oxygen consumption and aerobic scope of birds and mammals: getting to the h...
20838257 - Elite futsal refereeing: activity profile and physiological demands.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  47     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-9     Citation Subset:  IM    
Affiliation:
Center for Traumatic Stress, Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aversive Therapy / methods*
Chronic Disease
Conditioning, Classical*
Extinction, Psychological
Female
Galvanic Skin Response / physiology
Generalization (Psychology)
Heart Rate / physiology
Humans
Male
Psychometrics / statistics & numerical data
Stress Disorders, Post-Traumatic* / diagnosis,  psychology,  therapy
Grant Support
ID/Acronym/Agency:
MH-50379/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Developmental changes in postural sway in children at high and low risk for developing alcohol-relat...
Next Document:  Sleep in a community sample of elderly war veterans with and without posttraumatic stress disorder.