| Psychopharmacology of lycanthropy. | |
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MedLine Citation:
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PMID: 1555146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To develop pharmacotherapies for the orphan disease lycanthropy through the pursuit of the etiologic hypothesis of a genetically determined hypersecretion of endogenous lycanthropogens. DESIGN: Quadruple-blind, Rubik's Cube matrix analysis. SETTING: Community practice and malpractice. PARTICIPANTS: Subjects selected from inbred Ruficolla populations in Mississippi, Georgia, North Carolina and Minnesota. All who entered the study finished it. INTERVENTIONS: Chemical screening of blood samples over a hypothesized secretory cycle of lycanthropogen peaking on the day of maximum lunar illumination. Administration of synthetic lycanthropogens for behavioural testing. Experimental lycosomatization through the illumination method of Kirschbaum. OUTCOME MEASURES: None were post hoc, but some are still in hock. MAIN RESULTS: Two putative lycanthropogens were isolated from the blood samples. Structural elucidation and synthesis permitted animal and clinical trials; in each of these, behavioural dysfunction was observed. Antilycanthropogen strategies included application of the principle of caged compounds and generation of a therapeutic immunoglobulin. The effects of a newly developed antihirsutic agent seemed promising. An interaction of the lycanthropogen-secretion system and ethanol was noted, which may explain behavioural aspects of alcoholism. CONCLUSIONS: The incidence of lycomania in North America is underestimated. Soon-to-be-available pharmacotherapies should promote its early detection and treatment. Full control may depend upon advances in gene therapy. |
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Authors:
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W M Davis; H G Wellwuff; L Garew; O U Kydd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 146 ISSN: 0820-3946 ISO Abbreviation: CMAJ Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-05-04 Completed Date: 1992-05-04 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: CANADA |
Other Details:
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Languages: eng Pagination: 1191-7 Citation Subset: AIM; IM |
Affiliation:
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Orphan Drug Research Institute, Jefferson, Miss. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Delusions* Humans Wit and Humor as Topic* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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