| Psychopathology in offspring from families of alcohol dependent female probands: a prospective study. | |
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MedLine Citation:
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PMID: 20801463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite the importance of understanding the long-term outcome for children of alcohol dependent (AD) women, the available literature is largely based on offspring of AD fathers and few have utilized prospective designs that include child, adolescent and young adult assessments. Multiplex AD families in which multiple cases of AD are present provide an ideal setting for understanding developmental variants of the adult phenotype. METHOD: Offspring from multiplex AD families identified through the mother or control families were evaluated multiple times during childhood and followed to young adulthood. Familial risk status and the presence of specific child/adolescent disorders were used as predictors of substance use disorder outcome by young adulthood. RESULTS: Offspring who were members of maternal multiplex families had elevated rates of child and young adulthood disorders. High risk offspring of alcohol dependent women were at increased risk for externalizing (Conduct Disorder and ADHD) and internalizing disorders (Major Depressive Disorder (MDD) and Anxiety Disorders). By young adulthood, offspring from these multiplex families had significantly greater odds of developing alcohol abuse or dependence (odds ratio [OR] = 3.63 [CI 1.36-9.64]) and drug abuse or dependence (OR = 4.23 [CI 1.73-10.32]). The prospective design of the study revealed that specific childhood disorders (Conduct Disorder, ADHD, MDD) increased the odds of subsequent development of substance use disorder (SUD). CONCLUSIONS: Multiplex familial risk for alcohol dependence is a significant predictor of substance use disorders by young adulthood. Familial risk and an earlier childhood disorder may set the stage for later development of SUD. |
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Authors:
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Shirley Y Hill; Kevin D Tessner; Michael D McDermott |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of psychiatric research Volume: 45 ISSN: 1879-1379 ISO Abbreviation: J Psychiatr Res Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-06-14 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: England |
Other Details:
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Languages: eng Pagination: 285-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O' Hara St, Pittsburgh, PA 15213, USA. syh50@imap.pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alcoholism / complications*, genetics, mortality Child Child of Impaired Parents* Developmental Disabilities / etiology* Family Health* Female Humans Kaplan-Meier Estimate Longitudinal Studies Male Mental Disorders / diagnosis, etiology* Proportional Hazards Models Psychiatric Status Rating Scales Psychopathology* Risk Factors Sex Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AA 08082/AA/NIAAA NIH HHS; R01 AA008082-19/AA/NIAAA NIH HHS; R01 AA008082-20/AA/NIAAA NIH HHS; R01 AA018289/AA/NIAAA NIH HHS; R01 AA018289-03/AA/NIAAA NIH HHS |
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