| Psychopathological long-term outcome of schizophrenia - a review. | |
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MedLine Citation:
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PMID: 23136879 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: In the past, the comparability of empirical studies that examined the course and outcome of schizophrenia was limited by their use of different diagnostic systems. Focussing on the psychopathological long-term outcome, the present article aims to review follow-up studies that used modern operationalized diagnostic criteria for schizophrenia (DSM-III, DSM-III-R, DSM-IV and ICD-10). METHOD: We searched MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, PsycINFO and PSYNDEX for relevant studies up to the year 2011. Twenty-one studies were included in the final analysis. RESULTS: The long-term outcome of schizophrenia was heterogeneous and included full remissions as well as severe chronic states. Schizophrenia, however, showed a considerably more unfavourable outcome than other diagnostic groups such as schizoaffective or affective disorders. Psychopathological symptoms remained relatively stable in the course of illness. Several predictors for a poor outcome were identified, such as male gender or pronounced negative symptoms. CONCLUSION: Recent studies using modern diagnostic systems largely confirm the results of earlier studies. Current diagnostic criteria for schizophrenia identify a heterogeneous sample of patients. The influence of therapeutic interventions on long-term outcome remains unclear. |
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Authors:
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F U Lang; M Kösters; S Lang; T Becker; M Jäger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: Acta psychiatrica Scandinavica Volume: - ISSN: 1600-0447 ISO Abbreviation: Acta Psychiatr Scand Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Department of Psychiatry II, Ulm University, Ulm, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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