Document Detail


Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development.
MedLine Citation:
PMID:  21787802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well-established that psychological stress promotes immune dysregulation in nonpregnant humans and animals. Stress promotes inflammation, impairs antibody responses to vaccination, slows wound healing, and suppresses cell-mediated immune function. Importantly, the immune system changes substantially to support healthy pregnancy, with attenuation of inflammatory responses and impairment of cell-mediated immunity. This adaptation is postulated to protect the fetus from rejection by the maternal immune system. Thus, stress-induced immune dysregulation during pregnancy has unique implications for both maternal and fetal health, particularly preterm birth. However, very limited research has examined stress-immune relationships in pregnancy. The application of psychoneuroimmunology research models to the perinatal period holds great promise for elucidating biological pathways by which stress may affect adverse pregnancy outcomes, maternal health, and fetal development.
Authors:
Lisa M Christian
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-19
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  36     ISSN:  1873-7528     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-04-19     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  350-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Development* / immunology
Humans
Immune System / physiopathology*
Infant, Newborn
Infant, Premature, Diseases*
Male
Maternal Welfare*
Pregnancy / immunology*
Psychoneuroimmunology*
Stress, Psychological / immunology*
Grant Support
ID/Acronym/Agency:
R21 HD061644/HD/NICHD NIH HHS; R21 HD061644-01/HD/NICHD NIH HHS; R21 HD061644-02/HD/NICHD NIH HHS; R21 HD067670/HD/NICHD NIH HHS; R21 HD067670-01A1/HD/NICHD NIH HHS; R21HD061644/HD/NICHD NIH HHS; R21HD067670/HD/NICHD NIH HHS; UL1 RR025755/RR/NCRR NIH HHS; UL1 RR025755-05/RR/NCRR NIH HHS; UL1RR025755/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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