| Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development. | |
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MedLine Citation:
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PMID: 21787802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well-established that psychological stress promotes immune dysregulation in nonpregnant humans and animals. Stress promotes inflammation, impairs antibody responses to vaccination, slows wound healing, and suppresses cell-mediated immune function. Importantly, the immune system changes substantially to support healthy pregnancy, with attenuation of inflammatory responses and impairment of cell-mediated immunity. This adaptation is postulated to protect the fetus from rejection by the maternal immune system. Thus, stress-induced immune dysregulation during pregnancy has unique implications for both maternal and fetal health, particularly preterm birth. However, very limited research has examined stress-immune relationships in pregnancy. The application of psychoneuroimmunology research models to the perinatal period holds great promise for elucidating biological pathways by which stress may affect adverse pregnancy outcomes, maternal health, and fetal development. |
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Authors:
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Lisa M Christian |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-07-19 |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 36 ISSN: 1873-7528 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-11-21 Completed Date: 2012-04-19 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: United States |
Other Details:
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Languages: eng Pagination: 350-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH 43210, USA. Lisa.Christian@osumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetal Development* / immunology Humans Immune System / physiopathology* Infant, Newborn Infant, Premature, Diseases* Male Maternal Welfare* Pregnancy / immunology* Psychoneuroimmunology* Stress, Psychological / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R21 HD061644-01/HD/NICHD NIH HHS; R21 HD061644-02/HD/NICHD NIH HHS; R21 HD067670/HD/NICHD NIH HHS; R21 HD067670-01A1/HD/NICHD NIH HHS; R21HD061644/HD/NICHD NIH HHS; R21HD067670/HD/NICHD NIH HHS; UL1RR025755/RR/NCRR NIH HHS |
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