| Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. | |
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MedLine Citation:
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PMID: 22101513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course defined by symptomatic flares and remissions. The mechanisms of disease exacerbation are still poorly understood. Clinical occurrence of atopic dermatitis is often associated with psychological stress. In response to stress, upregulation of neuropeptide mediators in the brain, endocrine organs, and peripheral nervous system directly affect immune and resident cells in the skin. Lesional and non-lesional skin of patients with atopic dermatitis demonstrates increased mast cells and mast cell-nerve fiber contacts. In the setting of stress, sensory nerves release neuromediators that regulate inflammatory and immune responses, as well as barrier function. Progress towards elucidating these neuroimmune connections will refine our understanding of how emotional stress influences atopic dermatitis. Moreover, psychopharmacologic agents that modulate neuronal receptors or the amplification circuits of inflammation are attractive options for the treatment of not only atopic dermatitis, but also other stress-mediated inflammatory skin diseases. |
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Authors:
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Andrea L Suárez; Jamison D Feramisco; John Koo; Martin Steinhoff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 92 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-05 Completed Date: 2012-05-04 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 7-15 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Colorado Denver, School of Medicine, Aurora, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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metabolism Dermatitis, Atopic / immunology*, metabolism, physiopathology, psychology* Humans Hypothalamo-Hypophyseal System / metabolism Mast Cells Neuroimmunomodulation* Pituitary-Adrenal System / metabolism Receptors, Neurotransmitter / metabolism Stress, Psychological / immunology*, metabolism T-Lymphocytes |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR059402/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Receptors, Neurotransmitter |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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