Document Detail


A psychoneuroimmunologic examination of cumulative perinatal steroid exposures and preterm infant behavioral follow-up.
MedLine Citation:
PMID:  21900308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study's aim was to explore relationships between preterm infant behavioral outcomes and maternal/infant glucocorticoid (dexamethasone [DEX]) treatments using a psychoneuroimmunologic approach. Research questions were (a) do relationships exist between infant cumulative perinatal steroid (PNS) exposure and child behavioral problems? and (b) do maternal/infant characteristics (e.g., immune markers and biophysiologic stressors) influence these relationships?
METHODS: The convenience sample comprised 45 mother-child dyads in which the children (mean age 8 years ± 2.3) had been born at a mean postconceptional age of 28 weeks (± 4.2). We used the Child Behavior Checklist (CBCL) to assess behavior, the Clinical Risk Index for Babies (CRIB) to score stress at birth, and retrospective record review to identify additional perinatal factors (PNS dosage, sepsis, and maternal and infant complete blood counts near delivery).
RESULTS: Children were dichotomized into high (> 0.2 mg/kg; n = 20) versus low-no (≤0.2 mg/kg; n = 25) PNS exposure groups. Significant relationships existed between CBCL Total Problems score and sepsis, PNS exposure, timing of initial PNS, and infant length percentile at discharge. Competence problems were significantly associated with PNS, neonatal intensive care unit (NICU) infant length percentile, CRIB score, sepsis, retinopathy of prematurity, hearing deficit, and immunity markers (i.e., maternal lymphocyte percentage and infant band/seg ratio). Children in the higher PNS group exhibited more behavioral problems (e.g., withdrawn, attention, conduct, social, and rule breaking problems), but there were no significant differences. The findings are reassuring regarding long-term effects of this PNS dose on preterm infant behavioral outcomes.
Authors:
Isabell B Purdy; Lynne Smith; Dorothy Wiley; Lina Badr
Related Documents :
21631748 - Nursing and midwifery management of hypoglycaemia in healthy term neonates.
21985268 - Antenatal closure of the ductus arteriosus and hydrops fetalis.
22261508 - Clinical sepsis in neonates and young infants, united states, 1988-2006.
21775078 - Is it possible to predict the infant's neurodevelopmental outcome at 14 months of age b...
14511968 - Assessment of a structured in-hospital educational intervention addressing breastfeedin...
10724508 - Pathology of the heart and conduction system in a case of sudden death due to a cardiac...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-07
Journal Detail:
Title:  Biological research for nursing     Volume:  15     ISSN:  1552-4175     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-04-23     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-95     Citation Subset:  IM; N    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Glucocorticoids / administration & dosage*
Humans
Infant Behavior*
Infant, Newborn
Infant, Premature*
Maternal Exposure*
Pregnancy
Psychoneuroimmunology
Grant Support
ID/Acronym/Agency:
T32 NR0070077/NR/NINR NIH HHS; T32 NR007077/NR/NINR NIH HHS; UL1 TR000124/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Effect of Question Wording in Questionnaire Surveys on Placebo Use in Clinical Practice.
Next Document:  Sex Differences in Pain Responses at Maturity Following Neonatal Repeated Minor Pain Exposure in Rat...