Document Detail

Pharmepéna-Psychonautics: Human intranasal, sublingual and oral pharmacology of 5-methoxy-N,N-dimethyl-tryptamine.
MedLine Citation:
PMID:  11824699     Owner:  NLM     Status:  MEDLINE    
Summarized are psychonautic bioassays (human self-experiments) of pharmepéna--crystalline 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; O-Me-bufotenine), at times combined with crystalline beta-carbolines (harmaline or harmine). These substances were administered via intranasal, sublingual and oral routes, by way of pharmacological modeling of diverse South American shamanic inebriants (principally the snuffs epéna/nyakwana, prepared from barks of diverse species of Virola.) Intranasal, sublingual and oral psychoactivity of 5-MeO-DMT, and the 1967 Holmstedt-Lindgren hypothesis of the paricá-effect--intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAOI) beta-carbolines from stems of Banisteriopsis caapi admixed with the snuffs--have been confirmed by some 17 psychonautic bioassays. Salient phytochemical and psychonautic literature is reviewed.
J Ott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of psychoactive drugs     Volume:  33     ISSN:  0279-1072     ISO Abbreviation:  J Psychoactive Drugs     Publication Date:    2001 Oct-Dec
Date Detail:
Created Date:  2002-02-04     Completed Date:  2002-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8113536     Medline TA:  J Psychoactive Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Phantastica, Barcelona, Spain.
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MeSH Terms
Administration, Intranasal
Administration, Oral
Administration, Sublingual
Hallucinogens / administration & dosage,  pharmacology*
Harmaline / administration & dosage,  pharmacology
Harmine / administration & dosage,  pharmacology
Methoxydimethyltryptamines / administration & dosage,  pharmacology*
Monoamine Oxidase Inhibitors / pharmacology
Reg. No./Substance:
0/Hallucinogens; 0/Methoxydimethyltryptamines; 0/Monoamine Oxidase Inhibitors; 304-21-2/Harmaline; 442-51-3/Harmine

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