| Psychomotor agitation following gabapentin use in brain injury. | |
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MedLine Citation:
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PMID: 9210989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gabapentin, an anticonvulsant structurally related to gamma-aminobutyric acid (GABA) was recently reported to be effective in pain associated with reflex sympathetic dystrophy (RSD) and in pain associated with neuropathy. Yet, to our knowledge, the use of gabapentin for neuropathic pain in the presence of cognitive impairment has not been reported. In this report, we describe two patients (one with a traumatic brain injury, one with a putative acquired brain injury) who presented to a neurorehabilitation unit complaining of pain that was diagnosed as neurologically mediated. Within one week of receiving a daily 900 mg dose of gabapentin, both patients complained of heightened anxiety and restlessness. Correspondingly, each reported a diminution of psychological symptoms within 48 hours of gabapentin cessation. These two cases suggest that gabapentin may cause agitation in cognitive impaired patients. Physicians treating brain-injured patients and prescribing gabapentin for neuropathic pain may wish to closely monitor patients for similar signs of restlessness or anxiety. |
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Authors:
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M K Childers; D Holland |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Brain injury : [BI] Volume: 11 ISSN: 0269-9052 ISO Abbreviation: Brain Inj Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8710358 Medline TA: Brain Inj Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 537-40 Citation Subset: IM |
Affiliation:
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Department of Physical Medicine and Rehabilitation, University of Missouri-Columbia, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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adverse effects* Adult Akathisia, Drug-Induced / etiology* Amines* Analgesics / adverse effects* Brain Injuries / complications* Cyclohexanecarboxylic Acids* Humans Male Neuralgia / complications, drug therapy* Phantom Limb / complications, drug therapy* gamma-Aminobutyric Acid* |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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