Document Detail


Psychomotor Development of Children from an Iodine-Deficient Region.
MedLine Citation:
PMID:  21492867     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To assess the psychomotor development of the progeny of women from a moderately iodine-deficient area for whom thyroid function during pregnancy was measured. STUDY DESIGN: The development of 86 children was assessed by the Bayley Scale of Infant Development at 12, 18, and 24 months. RESULTS: Maternal serum free thyroxine (FT(4)) levels in the first trimester of pregnancy were the major determinant of psychomotor development at 18 and 24 months. Children born from mothers with FT(4) levels <25th percentile (<10 pg/mL) had an OR of 2.1 for mild-to-severe delay. Furthermore, alterations in behavior were already observed at 12 months and were related to subsequent changes in development. Neonatal thyroid status did not influence development. CONCLUSIONS: This study highlights the need to implement active measures of iodine supplementation periconceptionally and during pregnancy and lactation because the negative effects on development and behavior might be prevented through preemptive action.
Authors:
Maria José Costeira; Pedro Oliveira; Nadine Correia Santos; Susana Ares; Belen Saenz-Rico; Gabriella Morreale de Escobar; Joana Almeida Palha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-12
Journal Detail:
Title:  The Journal of pediatrics     Volume:  -     ISSN:  1097-6833     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal; the Centro Hospitalar Alto Ave-EPE, Guimarães, Portugal.
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