Document Detail

Psychometric and utility-based measures of health status of asthmatic patients with different disease control level.
MedLine Citation:
PMID:  15217309     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the relationship between asthma control level and health-related QOL (HR-QOL), and to understand the role of various psychometric and utility-based methods in studying this relationship. METHODS: Two hundred and twenty-eight consecutive adult outpatients and inpatients at four sites participated in the study. Physicians identified the level of disease control according to the Global Initiative for Asthma (GINA) classification system. Patients filled in three different HR-QOL questionnaires (EuroQol 5-D [EQ-5D], Short-Form 36-item health survey [SF-36], and St George's Respiratory Questionnaire [SGRQ]) and a direct time trade-off question. The Short Form-6D (SF-6D) was used to derive utility values from SF-36 data. RESULTS: All patient-reported evaluation methods could discriminate between patients with different disease control levels, and both generic and disease-specific instruments strongly correlated to each other. The magnitude of differences in HR-QOL between groups with different disease control levels was clinically meaningful. All three HR-QOL measures reflected a relationship between disease control level and HR-QOL, but the actual pattern of the relationship depended on the instrument used. Utilities gained from the EQ-5D index, compared with the SF-6D index, had higher values in the patient group with the best disease control and lower values in the patient group with poor disease control. CONCLUSION: When choosing an instrument to measure the health status of asthmatic patients in clinical studies, the severity range of the study population should be considered. Researchers might prefer to use the EQ-5D in asthma patients with severe disease or poor disease control and the SF-6D in patients with mild disease or good disease control.
Agota Szende; Klas Svensson; Elisabeth Ståhl; Agnes Mészáros; Gyula Y Berta
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  PharmacoEconomics     Volume:  22     ISSN:  1170-7690     ISO Abbreviation:  Pharmacoeconomics     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-25     Completed Date:  2004-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9212404     Medline TA:  Pharmacoeconomics     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  537-47     Citation Subset:  T    
MEDTAP International, London, UK.
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MeSH Terms
Asthma / physiopathology*,  prevention & control*,  psychology
Cross-Sectional Studies
Health Status*
Psychometrics / methods*
Quality of Life
Severity of Illness Index

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