| Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment. | |
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MedLine Citation:
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PMID: 21972117 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials. |
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Authors:
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Stephanie M Sansone; Keith F Widaman; Scott S Hall; Allan L Reiss; Amy Lightbody; Walter E Kaufmann; Elizabeth Berry-Kravis; Ave Lachiewicz; Elaine C Brown; David Hessl |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: - ISSN: 1573-3432 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, CA, 95817, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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