| Psychological stress and the progression of carotid artery disease. | |
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MedLine Citation:
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PMID: 9050970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We examined the relation between cardiovascular reactivity (the response of the cardiovascular system to psychological stress) and the severity and progression of carotid atherosclerosis. METHODS: Using duplex ultrasonography, we measured the change in the area of all detectable plaques in the extracranial carotid arteries during 2 years. Cardiovascular reactivity was assessed by measuring changes in hemodynamics during a frustrating cognitive task (the Stroop Color Word Interference Task). Established risk factors for atherosclerosis were measured by interviewing patients, a physical examination, and blood assays for 351 subjects with a wide range of types of atherosclerotic disease. RESULTS: Atherosclerotic plaques were present in the carotid arteries of 273 (78%) subjects. In a forward stepwise multiple regression analysis, it was found that greater age (beta = 0.46), a history of hypertension (beta = 0.20), use of lipid level-lowering agents (beta = 0.18), a longer history of smoking (beta = 0.13), a larger cholesterol:high-density lipoprotein ratio (beta = 0.13), a smaller change in heart rate during the task (beta = -0.12), and a higher resting systolic blood pressure (SBP; beta = 0.11) were associated significantly with a greater plaque area (R2 = 0.35). In 136 untreated subjects who were followed up for 2 years, a greater change in SBP during the task (beta = 0.28), a higher total cholesterol: high-density lipoprotein ratio (beta = 0.23), a shorter resting preejection period (beta = -0.19), and a lower body mass index (beta = -0.17) were significant predictors of the change in atherosclerosis, after controlling for age and initial plaque area in a stepwise multiple regression analysis (R2 = 0.24). CONCLUSIONS: These results support the hypothesis that hemodynamic responses under conditions of mental stress may influence the progression of atherosclerosis. |
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Authors:
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P A Barnett; J D Spence; S B Manuck; J R Jennings |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 15 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-06-03 Completed Date: 1997-06-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: IM |
Affiliation:
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London Health Sciences Centre and University of Western Ontario, London, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteriosclerosis / blood, etiology, ultrasonography Carotid Arteries / ultrasonography Carotid Artery Diseases / blood, etiology*, ultrasonography Cross-Sectional Studies Female Hemodynamics Humans Male Middle Aged Prospective Studies Risk Factors Stress, Psychological / complications* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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