Document Detail

Psychological and biological markers of stress and bacterial vaginosis in pregnant women.
MedLine Citation:
PMID:  17305894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether stress is associated with risk of bacterial vaginosis (BV) in pregnant women. DESIGN: Prospective cohort study. SETTING: The prenatal care clinics at the University of North Carolina. The residents' clinic sees mostly government-insured and uninsured women, and the physicians' clinic sees mostly those with private health insurance. POPULATION: A total of 897 women gave samples for BV analysis. Study participants were 22% African-American, 68% white; 24% unmarried and 44% nulliparous. More than half had completed college. METHODS: Women completed two questionnaires and two interviews reporting stress and psychological aspects of their lives. Measurement scales included the Sarason life events questionnaire, the Cohen perceived stress scale, Spielberger state-trait anxiety, the John Henryism coping style and the Medical Outcomes Study social support inventory. Two stress hormones, corticotrophin-releasing hormone and cortisol, were also measured. MAIN OUTCOME MEASURES: BV at 15-19 and 24-29 weeks of gestation was diagnosed by Gram's stain. RESULTS: Women in the highest quartile of stress measures, particularly state anxiety (OR=2.0, 95% CI 1.2-3.3), perceived stress (OR=2.4, 95% CI 1.5-3.9) and total life events (OR=2.0, 95% CI 1.3-3.2), had the highest risk of BV. Adjustment for confounders, especially age, race, and income, reduced these associations (state anxiety: OR=1.3, 95% CI 0.7-2.4; perceived stress: OR=1.4, 95% CI 0.8-2.5; total life events: OR=1.3, 95% CI 0.7-2.4). No clear pattern of association was seen between stress hormones and BV. CONCLUSIONS: Few associations between stress and BV were seen after adjustment for confounders.
E W Harville; D A Savitz; N Dole; J M Thorp; A H Herring
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  114     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-03-15     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  216-23     Citation Subset:  AIM; IM    
Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
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MeSH Terms
Biological Markers / blood
Cohort Studies
Corticotropin-Releasing Hormone / metabolism
Hydrocortisone / metabolism
Odds Ratio
Pregnancy Complications / blood,  psychology*
Pregnancy Complications, Infectious / blood,  psychology
Prospective Studies
Saliva / chemistry
Stress, Psychological / complications*
Vaginosis, Bacterial / blood,  psychology*
Grant Support
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone

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