| Psychological and biological markers of stress and bacterial vaginosis in pregnant women. | |
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MedLine Citation:
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PMID: 17305894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether stress is associated with risk of bacterial vaginosis (BV) in pregnant women. DESIGN: Prospective cohort study. SETTING: The prenatal care clinics at the University of North Carolina. The residents' clinic sees mostly government-insured and uninsured women, and the physicians' clinic sees mostly those with private health insurance. POPULATION: A total of 897 women gave samples for BV analysis. Study participants were 22% African-American, 68% white; 24% unmarried and 44% nulliparous. More than half had completed college. METHODS: Women completed two questionnaires and two interviews reporting stress and psychological aspects of their lives. Measurement scales included the Sarason life events questionnaire, the Cohen perceived stress scale, Spielberger state-trait anxiety, the John Henryism coping style and the Medical Outcomes Study social support inventory. Two stress hormones, corticotrophin-releasing hormone and cortisol, were also measured. MAIN OUTCOME MEASURES: BV at 15-19 and 24-29 weeks of gestation was diagnosed by Gram's stain. RESULTS: Women in the highest quartile of stress measures, particularly state anxiety (OR=2.0, 95% CI 1.2-3.3), perceived stress (OR=2.4, 95% CI 1.5-3.9) and total life events (OR=2.0, 95% CI 1.3-3.2), had the highest risk of BV. Adjustment for confounders, especially age, race, and income, reduced these associations (state anxiety: OR=1.3, 95% CI 0.7-2.4; perceived stress: OR=1.4, 95% CI 0.8-2.5; total life events: OR=1.3, 95% CI 0.7-2.4). No clear pattern of association was seen between stress hormones and BV. CONCLUSIONS: Few associations between stress and BV were seen after adjustment for confounders. |
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Authors:
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E W Harville; D A Savitz; N Dole; J M Thorp; A H Herring |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 114 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-19 Completed Date: 2007-03-15 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 216-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. Harville@tulane.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Cohort Studies Corticotropin-Releasing Hormone / metabolism Female Humans Hydrocortisone / metabolism Odds Ratio Pregnancy Pregnancy Complications / blood, psychology* Pregnancy Complications, Infectious / blood, psychology Prospective Studies Questionnaires Saliva / chemistry Stress, Psychological / complications* Vaginosis, Bacterial / blood, psychology* |
| Grant Support | |
ID/Acronym/Agency:
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DK61981/DK/NIDDK NIH HHS; HD37584/HD/NICHD NIH HHS; HD39373/HD/NICHD NIH HHS; RR00046/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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