Document Detail

Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample.
MedLine Citation:
PMID:  17459660     Owner:  NLM     Status:  MEDLINE    
The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular.
Marco P M Boks; Marjolein H T de Vette; Iris E Sommer; Sophie van Rijn; Jacques C Giltay; Hanna Swaab; René S Kahn
Publication Detail:
Type:  Journal Article     Date:  2007-04-24
Journal Detail:
Title:  Schizophrenia research     Volume:  93     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-30     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands.
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MeSH Terms
Chromosomes, Human, X / genetics*
Cross-Sectional Studies
Genetic Predisposition to Disease / genetics
Klinefelter Syndrome / diagnosis,  epidemiology,  genetics*,  psychology
Mental Disorders / diagnosis,  epidemiology,  genetics*
Middle Aged
Psychotic Disorders / diagnosis,  genetics,  psychology
Schizophrenia / diagnosis,  genetics
Schizophrenic Psychology
Sex Chromosome Aberrations*

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