Document Detail

Psychiatric and hostility factors related to use of anabolic steroids in monozygotic twins.
MedLine Citation:
PMID:  16529916     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Anabolic androgenic steroids (AAS) are derived by chemical manipulation of the testosterone molecule. The specified category of drugs produces anabolic, androgenic and psycho-active effects including elevated aggressive, hostile, violent and anti social behavior. OBJECTIVE: The objective of this case report observational study was to evaluate the possible psychological consequences of AS use in the twin user of each pair, compared with the non-user twin. METHODOLOGY: We studied two pairs of male monozygotic twins: one pair 24 years old and the other 31 years old, with absolute genome and phenotype similarity. One of the twins of each pair used AAS while the other did not. Both pairs lived in Hellenic provincial towns and followed a common training and nutrition regime. The psychometric instruments used were the Symptoms Check List-90 (SCL-90) and the Hostility and Direction of Hostility Questionnaire (HDHQ). The psychometric evaluations took place within a time interval of 6 months. RESULTS: The study found high levels of aggressiveness, hostility, anxiety and paranoid ideation in the twins who used AS. The non-user twins showed no deviation from their initial status. CONCLUSION: The use of AAS induced several important psychiatric changes in monozygotic twins which were not present in the twin who did not use AAS.
Thomas A Pagonis; Nikiforos V Angelopoulos; George N Koukoulis; Christos S Hadjichristodoulou; Paraskevi N Toli
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Publication Detail:
Type:  Comparative Study; Journal Article; Twin Study     Date:  2006-03-10
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  21     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  563-9     Citation Subset:  IM    
Department of Psychiatry, Thessaly University Medical School, Panagouli 12, 41222 Larissa, Greece.
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MeSH Terms
Aggression / drug effects,  psychology
Anabolic Agents / adverse effects*
Anxiety / chemically induced,  psychology
Doping in Sports / methods,  psychology*,  statistics & numerical data
Mental Disorders / chemically induced*,  psychology*
Paranoid Behavior / chemically induced,  psychology
Psychiatric Status Rating Scales
Psychometrics / methods
Steroids / adverse effects*
Stress, Psychological / chemically induced,  diagnosis,  psychology
Substance-Related Disorders / diagnosis,  psychology*
Time Factors
Twins, Monozygotic / drug effects,  psychology
Reg. No./Substance:
0/Anabolic Agents; 0/Steroids

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