Document Detail


Psychiatric findings in Wolfram syndrome homozygotes.
MedLine Citation:
PMID:  1975860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetes mellitus and bilateral optic atrophy are the defining characteristics of the autosomal recessive Wolfram syndrome. Diabetes insipidus, neurogenic bladder, deafness, and other neurological manifestations are frequent. A review was made of the medical records of 68 Wolfram syndrome patients, aged between 8 and 43 years, identified by casefinding throughout the USA. 41 of the patients (60%) had episodes of severe depression, psychosis, or organic brain syndrome, as well as impulsive verbal and physical aggression. These symptoms were very severe in 17 patients (25%), of whom 12 required admission to a psychiatric hospital and 11 attempted suicide. We conclude that the Wolfram syndrome gene predisposes homozygotes to psychiatric illness.
Authors:
R G Swift; D B Sadler; M Swift
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  336     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-12     Completed Date:  1990-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  667-9     Citation Subset:  AIM; IM    
Affiliation:
Biological Sciences Research Center, University of North Carolina, Chapel Hill 27599.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Delirium, Dementia, Amnestic, Cognitive Disorders / drug therapy,  etiology
Depressive Disorder / drug therapy,  etiology
Disease Susceptibility
Female
Homozygote*
Humans
Infant
Infant, Newborn
Male
Medical Records
Mental Disorders / drug therapy,  etiology*
Middle Aged
Psychotic Disorders / drug therapy,  etiology
Questionnaires
Retrospective Studies
Suicide, Attempted / psychology
Wolfram Syndrome / complications*,  genetics
Grant Support
ID/Acronym/Agency:
AM28135/AM/NIADDK NIH HHS; HD 03110/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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