Document Detail

Psychiatric morbidity is linked to problem drinking in midlife among alcohol-dependent men: a co-twin control study.
MedLine Citation:
PMID:  23200159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Prior research on predictors of problem drinking has been limited because of an inability to attribute an unambiguous environmental explanation to observed findings. Using a prospective co-twin control design, we examined the extent to which a history of psychiatric symptoms exerts an environmental influence on problem drinking in midlife that is unconfounded by genetic underpinnings.
METHOD: Participants were 367 complete male twin pairs (208 monozygotic, 159 dizygotic) from the Vietnam Era Twin Registry who were assessed in midlife as part of the Family Twin Study (Mage = 51.4 years, SD = 2.8). Twin pairs who were concordant for a lifetime diagnosis of an alcohol use disorder (AUD) in 1992 were selected for participation and were reinterviewed in 2001 to measure symptoms of AUD (i.e., problem drinking) since the prior assessment (past 10 years).
RESULTS: Within-pair differences in lifetime symptom counts of several psychiatric disorders measured in 1992 (i.e., major depression, dysthymia, generalized anxiety disorder, panic disorder, antisocial personality, mania, and posttraumatic stress disorder) were significantly associated with within-pair differences in AUD symptoms in the subsequent 10 years.
CONCLUSIONS: A history of psychiatric problems, particularly one marked by internalizing symptoms, appears to be linked to problem drinking in midlife above and beyond the confounding influence of genetic effects and underscores the potential value of integrated interventions for comorbidity to address problem drinking among individuals during this period of the life course.
Daniel M Blonigen; Thomas Burroughs; Jon Randolph Haber; Theodore Jacob
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of studies on alcohol and drugs     Volume:  74     ISSN:  1938-4114     ISO Abbreviation:  J Stud Alcohol Drugs     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-14     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101295847     Medline TA:  J Stud Alcohol Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
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MeSH Terms
Alcoholism / epidemiology*
Diagnosis, Dual (Psychiatry)
Mental Disorders / epidemiology*,  physiopathology
Middle Aged
Prospective Studies
Retrospective Studies
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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