Document Detail


Psoriatic juvenile idiopathic arthritis: a tale of two subgroups.
MedLine Citation:
PMID:  21709556     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The International League of Associations for Rheumatology criteria parse out juvenile idiopathic arthritis (JIA) into seven groups, with the aim of creating homogeneous subgroups suitable for clinical and research evaluation. However, prior studies have shown that psoriatic JIA (psJIA) may be a heterogeneous entity. RECENT FINDINGS: PsJIA is composed of two subgroups, differentiated by age at onset. Older children with psJIA have features of spondyloarthritis, including relative male preponderance, increased risk of axial involvement, and enthesitis. Extrapolating from studies on adults with psoriatic arthritis, the mechanism of older-onset PsJIA appears to involve autoinflammatory dysregulation centered at the synovial-entheseal complex; there may also be a role for gut inflammation in a subset of patients. In contrast, patients with early-onset PsJIA bear similarities to early-onset oligoarticular and polyarticular JIA patients, including female preponderance, antinuclear antibody (ANA) positivity, and certain human leukocyte antigen types, suggesting a possible role for traditional autoimmune mechanisms. Both groups, however, share a high frequency of dactylitis. SUMMARY: This review demonstrates that PsJIA is a heterogeneous entity, with different clinical, genetic, and possibly pathophysiological features. Future studies are needed to explore the mechanisms of arthritis in both subgroups, particularly in the early-onset children.
Authors:
Matthew L Stoll; Marilynn Punaro
Related Documents :
19587696 - Autoantigens in vitiligo identified by the serological selection of a phage-displayed m...
6658306 - Evaluation of a new filter for membrane plasma separation (preliminary observations).
22538076 - Hemorrhage/contrast staining areas after mechanical intra-arterial thrombectomy in acut...
6467676 - Association of anti-heart antibodies and circulating immune complexes in the post-peric...
24284086 - Risk factors for developing oral 5-aminolevulenic acid-induced side effects in patients...
21454196 - Factors predicting transformation of asymptomatic igm monoclonal gammopathy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-24
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  -     ISSN:  1531-6963     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Pediatrics, University of Texas Southwestern Medical Center bDepartment of Rheumatology, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Kidney paired donation: advancements and future directions.
Next Document:  Aging and osteoarthritis.