Document Detail

Psoriatic erythroderma: a histopathologic study of forty-five patients.
MedLine Citation:
PMID:  9094455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There are conflicting opinions about the diagnostic value of skin biopsy in erythrodermic psoriasis. OBJECTIVE: The purpose of the present study was to establish the specificity of the histopathologic changes of psoriatic erythroderma. METHODS: We reviewed 52 skin biopsies from 45 erythrodermic patients having a final diagnosis of psoriasis on the basis of combined clinical and laboratory data, in addition to response to therapy and follow-up. In 5 patients, erythroderma was the presenting sign of psoriasis. A control group of nonpsoriatic erythrodermic patients was also included in the study. RESULTS: Among the group of patients with a discharge diagnosis of psoriatic erythroderma, the histopathologic changes were specific for psoriasis in 40 cases (88%). The changes of early macular and squamous lesions of psoriasis were more often found in the biopsy specimens of our series than those of fully developed or late lesions of psoriasis. They included mainly slight epidermal hyperplasia, focal disappearance of the granular layer, mounds of parakeratosis and extravasated erythrocytes within edematous dermal papillae associated with perivascular and interstitial infiltration of lymphocytes and histiocytes. CONCLUSION: When features of early lesions of psoriasis are found during the evaluation of a biopsy specimen from a patient with a clinically nonspecific erythroderma, the dermatopathologist should be aware that this patient could have psoriasis and a renewed anamnesis and a close follow-up should be made.
C Tomasini; F Aloi; C Solaroli; M Pippione
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  194     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1997  
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Department of Dermatology, University of Turin, Italy.
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MeSH Terms
Aged, 80 and over
Dermatitis, Exfoliative / diagnosis,  pathology*,  therapy
Drug Eruptions / pathology
Edema / pathology
Epidermis / pathology
Erythrocytes / pathology
Follow-Up Studies
Histiocytes / pathology
Keratosis / pathology
Lymphocytes / pathology
Lymphoma, T-Cell, Cutaneous / pathology
Middle Aged
Mycosis Fungoides / pathology
Pityriasis Rubra Pilaris / pathology
Psoriasis / diagnosis,  pathology*,  therapy
Sezary Syndrome / pathology
Skin Neoplasms / pathology

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