| Psoriatic erythroderma: a histopathologic study of forty-five patients. | |
| | |
MedLine Citation:
|
PMID: 9094455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: There are conflicting opinions about the diagnostic value of skin biopsy in erythrodermic psoriasis. OBJECTIVE: The purpose of the present study was to establish the specificity of the histopathologic changes of psoriatic erythroderma. METHODS: We reviewed 52 skin biopsies from 45 erythrodermic patients having a final diagnosis of psoriasis on the basis of combined clinical and laboratory data, in addition to response to therapy and follow-up. In 5 patients, erythroderma was the presenting sign of psoriasis. A control group of nonpsoriatic erythrodermic patients was also included in the study. RESULTS: Among the group of patients with a discharge diagnosis of psoriatic erythroderma, the histopathologic changes were specific for psoriasis in 40 cases (88%). The changes of early macular and squamous lesions of psoriasis were more often found in the biopsy specimens of our series than those of fully developed or late lesions of psoriasis. They included mainly slight epidermal hyperplasia, focal disappearance of the granular layer, mounds of parakeratosis and extravasated erythrocytes within edematous dermal papillae associated with perivascular and interstitial infiltration of lymphocytes and histiocytes. CONCLUSION: When features of early lesions of psoriasis are found during the evaluation of a biopsy specimen from a patient with a clinically nonspecific erythroderma, the dermatopathologist should be aware that this patient could have psoriasis and a renewed anamnesis and a close follow-up should be made. |
| | |
Authors:
|
C Tomasini; F Aloi; C Solaroli; M Pippione |
Related Documents
:
|
7585915 - Ante-mortem diagnosis of human rabies by the skin biopsy technique: three case reports ... 23169245 - Clinical-pathologic correlation between transperineal mapping biopsies of the prostate ... 10384915 - Expression of p53 protein before and after puva treatment in psoriasis. 23634155 - Individual applicator for brachytherapy for various sites of superficial malignant lesi... 11592525 - Bilateral subpleural ectopic brain tissue in a 23-week-old fetus. 18077525 - Usefulness of 11c-methionine for differentiating tumors from granulomas in experimental... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Dermatology (Basel, Switzerland) Volume: 194 ISSN: 1018-8665 ISO Abbreviation: Dermatology (Basel) Publication Date: 1997 |
Date Detail:
|
Created Date: 1997-06-19 Completed Date: 1997-06-19 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9203244 Medline TA: Dermatology Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 102-6 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, University of Turin, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Biopsy Dermatitis, Exfoliative / diagnosis, pathology*, therapy Drug Eruptions / pathology Edema / pathology Epidermis / pathology Erythrocytes / pathology Female Follow-Up Studies Histiocytes / pathology Humans Hyperplasia Keratosis / pathology Lymphocytes / pathology Lymphoma, T-Cell, Cutaneous / pathology Male Middle Aged Mycosis Fungoides / pathology Pityriasis Rubra Pilaris / pathology Psoriasis / diagnosis, pathology*, therapy Sezary Syndrome / pathology Skin Neoplasms / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Idiopathic erythroderma: a follow-up study of 28 patients.
Next Document: Extracorporeal photochemotherapy induces a significant increase in CD36+ circulating monocytes in pa...