Document Detail

Psoriatic architecture constructed by epidermal remodeling.
MedLine Citation:
PMID:  15265521     Owner:  NLM     Status:  MEDLINE    
Epidermal remodeling is the concept that epidermal architecture is determined by a simple self-organizing mechanism; epidermal hyperproliferation constructs typical psoriatic architecture. This is based on the assumption that the enlargements in both the two-dimensional proliferative compartment (basal cell layer) and three-dimensional whole epidermal volume coexist. During this process, the dermal papillae become markedly, but passively, expanded by enlargement of the proliferative compartment. This creates a considerable shrinkage force against the crowded basal cell layer, which is forced to lose adherence to the dermal extracellular matrix (ECM). This results in anoikis, a type of apoptosis characterized by cell detachment, and, consequently, a markedly diminished epidermal turnover time in psoriasis. The papillary shrinkage force also explains the fact that dermal papillary height does not exceed a certain limit. At the cessation of hyperproliferation a normalisation remodeling takes place toward normal tissue architecture. Thus the concept of epidermal remodeling explains the self-organizing mechanism of the architectural change in psoriasis, which is essentially a reversible disorder depending on epidermal hyperproliferation.
Hajime Iizuka; Hidetoshi Takahashi; Akemi Ishida-Yamamoto
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of dermatological science     Volume:  35     ISSN:  0923-1811     ISO Abbreviation:  J. Dermatol. Sci.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-21     Completed Date:  2005-02-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9011485     Medline TA:  J Dermatol Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
Department of Dermatology, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1, Asahikawa, Japan.
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MeSH Terms
Cell Division
Epidermis / pathology*,  physiopathology
Psoriasis / pathology*,  physiopathology
Stem Cells / pathology

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