| Psoriasis triggered by mefloquine. | |
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MedLine Citation:
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PMID: 21137644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 46-year-old Caucasian man living on the central Mediterranean island of Gozo (Malta) was started on mefloquine 250 mg once weekly before a trip to lower Egypt. He took his medication 1 week before starting his holiday and was advised to continue it for 4 weeks after returning. He did not take any other medication and enjoyed the holiday, which he initially intended to repeat in the near future. His medical history revealed a number of episodes of psoriasis for which he sought dermatologic advice. He had been given systemic therapy on at least one occasion, but the condition had been fairly quiescent for some time and he had not needed to consult a dermatologist for more than 4 years. Soon after the third tablet of mefloquine and effectively just after his return home to Gozo, the patient noticed that the psoriasis was "creeping back." He noted progressive deterioration in his skin problem but nevertheless finished the recommended course of therapy considering that "being sure about not developing malaria was far more important than a touch of psoriasis." The psoriasis worsened to the extent that he had taken off work for 2 weeks from his job as a self-employed carpenter at the time of referral. On examination, clearly there was a significant flare up of his psoriasis with severe involvement of the hands (Figure 1) and feet and less so over the rest of his body. He had been off work and matters were steadily getting worse in spite of topical treatment with a combination of calcipotriol-betamethasone ointment. Oral methotrexate 15 mg once weekly was commenced together with topical therapy with good results (Figure 2). |
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Authors:
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Joseph L Pace |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Skinmed Volume: 8 ISSN: 1540-9740 ISO Abbreviation: Skinmed Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168327 Medline TA: Skinmed Country: United States |
Other Details:
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Languages: eng Pagination: 301-2 Citation Subset: IM |
Affiliation:
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University of Malta Medical School, Malta. josephlpace@onvol.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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adverse effects*,
therapeutic use Betamethasone / administration & dosage, therapeutic use Calcitriol / administration & dosage, analogs & derivatives, therapeutic use Dermatologic Agents / administration & dosage, therapeutic use Drug Therapy, Combination Humans Malaria / prevention & control Male Mefloquine / adverse effects*, therapeutic use Methotrexate / therapeutic use Middle Aged Psoriasis / etiology*, pathology Severity of Illness Index Travel |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Dermatologic Agents; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol; 378-44-9/Betamethasone; 53230-10-7/Mefloquine; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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