Document Detail

Psoriasis and pregnancy outcomes: a nationwide population-based study.
MedLine Citation:
PMID:  20970879     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous research regarding pregnancy outcomes in women with psoriasis either used selective hospital-based data, or analyzed obstetric, but not infant-specific, outcomes.
OBJECTIVE: We sought to investigate whether maternal psoriasis was associated with increased risk of adverse pregnancy outcomes, compared with unaffected mothers, in an unselected nationwide population-based data set.
METHODS: In total, 1463 mothers with psoriasis and 11,704 randomly selected mothers without psoriasis were included. Of the 1463 mothers with psoriasis, 645 (44.1%) who had received photochemotherapy or systemic therapy within 2 years before their index deliveries were put in the severe psoriasis group. Conditional logistic regression analyses were conducted to calculate the risk of low birth weight (LBW), preterm birth, cesarean section, small for gestational age, and preeclampsia or eclampsia for these two groups, after adjusting for characteristics of the mother, father, and infant.
RESULTS: The odds of LBW for women with severe psoriasis were 1.40 times those of mothers without psoriasis (95% confidence interval = 1.04-1.89) after adjusting for characteristics of the mother, father, and infant. However, mothers with mild psoriasis had no significantly higher odds of LBW, preterm birth, cesarean section, infants small for gestational age, and preeclampsia or eclampsia compared with those without psoriasis.
LIMITATIONS: Patients with psoriasis were identified by diagnostic code in database, resulting in the possibility of misclassification bias. In addition, lack of information regarding maternal risk behaviors and previous adverse pregnancy outcomes may leave residual confounding.
CONCLUSION: We found that pregnant women with severe psoriasis had an increased risk of LBW infants, whereas mild psoriasis was not associated with excess risk of adverse birth outcomes.
Ya-Wen Yang; Chin-Shyan Chen; Yi-Hua Chen; Herng-Ching Lin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  64     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Department of Dermatology, Taipei Medical University and Hospital, Taipei, Taiwan.
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MeSH Terms
Confidence Intervals
Cross-Sectional Studies
Databases, Factual
Delivery, Obstetric / methods
Follow-Up Studies
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Odds Ratio
Photochemotherapy / methods
Pregnancy Complications / etiology*,  physiopathology,  therapy
Pregnancy Outcome*
Prenatal Care / methods
Psoriasis / complications*,  diagnosis,  therapy
Reference Values
Risk Assessment
Severity of Illness Index
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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