Document Detail

Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution.
MedLine Citation:
PMID:  6179364     Owner:  NLM     Status:  MEDLINE    
The variation in expression of psoriasis, in individuals with identical genetic constitutions, i.e. monozygotic twins, has been studied in a population-based sample of monozygotic twins in the Danish Twin Register. All verified and probable cases of psoriasis in twins, born between 1891 and 1930 inclusive, were ascertained. Results are presented of an examination of all members of index pairs in which both partners were alive. The zygosity determination was based in 94% of the pairs on very extensive serological examinations. Thirty-two monozygotic pairs were found to include at least one partner with unquestionable psoriasis (18 concordant, 14 discordant). The analyses give firm evidence of the contribution of genetic factors to the manifestation, age at onset, clinical type, course, and severity of psoriasis. A close association between psoriasis and HLA-B 13 an B 17 was found in both discordant and concordant pairs. No difference was found between partners from discordant MZ-pairs with regard to infections or marked 'stress' conditions.
F Brandrup; N Holm; N Grunnet; K Henningsen; H E Hansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  62     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
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MeSH Terms
Diseases in Twins*
HLA Antigens / analysis
HLA-B Antigens
Middle Aged
Psoriasis / epidemiology,  genetics*
Twins, Monozygotic*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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