| Psoriasis: from pathogenesis to novel therapeutic approaches. | |
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MedLine Citation:
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PMID: 20846119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines produced by these cells stimulate keratinocytes to proliferate and increase the migration of inflammatory cells into the skin, promoting epidermal hyperplasia and inflammation. Understanding the immunology of the psoriatic plaque has led to new therapeutic options and novel candidates for immunomodulation, and has changed the ways psoriatic patients are managed. |
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Authors:
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Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald; Sergio Chimenti; Antonio Costanzo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 120 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-11-23 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Gastroenterology Unit, Internal Medicine Department, University Tor Vergata of Rome, 00133 Rome, Italy. gi.monteleone@med.uniroma2.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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immunology Dermatologic Agents / therapeutic use Genetic Predisposition to Disease Humans Immunity, Innate Immunosuppressive Agents / therapeutic use Psoriasis / drug therapy, etiology*, immunology T-Lymphocyte Subsets / immunology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Dermatologic Agents; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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