Document Detail

Psoriasis, anti-tumor necrosis factor therapy, and tuberculosis: report of three challenging cases and literature review.
MedLine Citation:
PMID:  25135824     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: The era of biologic therapies has provided new options for the treatment of chronic plaque psoriasis. However, safety concerns have led to intensive screening and monitoring of patients receiving anti-tumor necrosis factor alpha (anti-TNF-alpha) agents.
METHODS: The authors describe the cases of three patients with moderate to severe psoriasis treated with anti-TNF agents, with challenging diagnostic and treatment aspects regarding tuberculosis (TB) infection, a serious adverse event associated with this type of treatment. The cases are discussed in the context of a comprehensive literature review describing the risk of TB associated with the use of TNF inhibitors. A critical review of the clinical trials that have tested the safety of these agents is also presented.
RESULTS: One patient, who tested negatively for latent TB infection (LTBI) during screening, developed active TB under adalimumab therapy. For two other patients the diagnosis and management of LTBI in relation to anti-TNF therapy represented a challenge. Although clinical trials involving the use of anti-TNF therapy for psoriasis haven't demonstrated a high TB incidence, active TB is continuously reported in association with this treatment.
CONCLUSIONS: Findings from clinical practice and the scientific literature indicate that anti-TNF therapies are associated with an increased risk of TB, and close monitoring of patients is needed.
Caius Solovan; Elena Chiticariu
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Publication Detail:
Type:  Journal Article     Date:  2013-02-15
Journal Detail:
Title:  Infectious diseases and therapy     Volume:  2     ISSN:  2193-8229     ISO Abbreviation:  Infect Dis Ther     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2014-08-19     Completed Date:  2014-08-19     Revised Date:  2014-08-22    
Medline Journal Info:
Nlm Unique ID:  101634499     Medline TA:  Infect Dis Ther     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  59-73     Citation Subset:  -    
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