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Psoriasin: a novel marker linked obesity with psoriasis.
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MedLine Citation:
PMID:  23151615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the role of psoriasin, koebnerisin, interleukn (IL)-12 and IL-23 in the pathogenesis of psoriasis and their relations to Psoriasis Area Severity Index (PASI) and obesity. Thirty patients had chronic plaque psoriasis and 30 healthy subjects matched in age and sex were enrolled in this study. Serum from all subjects were used for determination of psoriasin, koebnerisin, IL-12 and IL-23 by ELISA kits. IL-23 and psoriasin were significantly higher in skin psoriasis compared to controls and psoriatic arthritis (PsA). There was a correlation between psoriasin and both PASI and obesity. On the other hand, IL-12 was significantly increased in PsA compared to skin psoriasis (p=0.000) and controls. Its sensitivity and specificity were 87%, 93%; respectively. To our knowledge, psoriasin is the first biomarker confirm the link between obesity and psoriasis. The risk of developing psoriasis is directly related to higher BMI.
Authors:
Ragaa H M Salama; Hani A Al-Shobaili; Ahmad A Al Robaee; Abdullateef A Alzolibani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  34     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-28     Revised Date:  2013-12-30    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
Case-Control Studies
Female
Humans
Interleukin-12 / blood
Interleukin-23 / blood
Male
Middle Aged
Obesity / blood*
Psoriasis / blood*
ROC Curve
Risk
S100 Proteins / blood*
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-23; 0/S100 Proteins; 0/S100A7 protein, human; 0/S100A7A protein, human; 187348-17-0/Interleukin-12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2013 Hindawi Publishing Corporation.
Received Day: 12 Month: 11 Year: 2012
Accepted Day: 12 Month: 11 Year: 2012
Print publication date: Year: 2013
Electronic publication date: Day: 17 Month: 12 Year: 2012
Volume: 34 Issue: 1
First Page: 33 Last Page: 39
PubMed Id: 23151615
ID: 3809746
Article Id: 659864
DOI: 10.3233/DMA-2012-120945

Psoriasin: A Novel Marker Linked Obesity with Psoriasis
Ragaa H. M. Salama1*
Hani A. Al-Shobaili2
Ahmad A. Al Robaee2
Abdullateef A. Alzolibani2
1Department of Medical BiochemistryCollege of MedicineQassim UniversityQassimKSA
2Department of DermatologyCollege of MedicineQassim UniversityQassimKSA
Correspondence: *Ragaa H. M. Salama: ragaa_2002@yahoo.com


Article Categories:
  • Other

Keywords: Psoriasis, psoriasin, kobneriasin, IL-12, IL-23, obesity.

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