Document Detail

Psoriasiform eruption induced by infliximab.
MedLine Citation:
PMID:  14742794     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of psoriasiform eruption induced by infliximab. CASE SUMMARY: A 46-year-old woman with enterocutaneous fistula secondary to Crohn's disease developed pruriginous, erythematous, desquamative plaques on her elbows, knees, hands, and buttocks after receiving the second and third doses of intravenous infliximab. Histologic examination showed a lichenoid pattern. No new cutaneous lesions appeared after cessation of infliximab therapy. DISCUSSION: Several cutaneous reactions secondary to infliximab, a monoclonal antibody against tumor necrosis factor-alfa, have been described. Psoriasiform dermatitis has not been reported as a cutaneous reaction to infliximab, but there have been several previous reports of psoriasiform dermatitis secondary to other drugs. An objective causality assessment revealed that the adverse event was probable. CONCLUSIONS: This is the first report of a clinico-pathologic dissociated pattern of cutaneous reaction showing a histopathologic picture of lichenoid dermatitis resulting from infliximab treatment.
María M Verea; Jesús Del Pozo; M Teresa Yebra-Pimentel; Angeles Porta; Eduardo Fonseca
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  38     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain.
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MeSH Terms
Administration, Topical
Antibodies, Monoclonal / administration & dosage,  adverse effects*,  pharmacokinetics
Crohn Disease / complications,  pathology
Drug Eruptions / complications*,  drug therapy,  pathology
Hand Dermatoses / chemically induced,  complications,  drug therapy
Injections, Intravenous
Intestinal Fistula / complications,  pathology
Lichenoid Eruptions / chemically induced,  complications,  drug therapy
Methylprednisolone / administration & dosage,  analogs & derivatives*,  therapeutic use
Middle Aged
Psoriasis / chemically induced*,  complications*,  drug therapy
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/infliximab; 53-36-1/methylprednisolone acetate; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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