Document Detail


Psoralen photochemotherapy (PUVA) and pregnancy.
MedLine Citation:
PMID:  7772086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND DESIGN: Psoralen photochemotherapy (PUVA) may carry a risk of mutagenesis and teratogenesis. Using a medical birth registry and other health registries, infants born to women who had been treated with PUVA were identified. Exposure information was obtained from treating hospitals and from the license-granting agency. A total of 504 infants were born of pregnancies occurring after PUVA treatment, and 689 infants were born of pregnancies occurring before such treatment. In another 14 cases, treatment occurred during pregnancy. RESULTS: No increase in infant or child mortality or in the presence of congenital malformations could be seen after PUVA treatment. There was a marked increase in low-birth-weight infants when pregnancy occurred after treatment, and this is probably not explained by maternal smoking, but could be an effect of the underlying disease. CONCLUSIONS: The theoretical mutagenic and teratogenic effect of PUVA treatment apparently does not carry any significant risk for abnormal delivery outcome.
Authors:
J G Gunnarskog; A J K?ll?n; B G Lindel?f; B Sigurgeirsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  129     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  320-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology, National Board of Health, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / epidemiology*,  etiology
Adult
Birth Weight
Female
Fetal Death
Humans
Infant, Newborn
Male
Maternal Age
PUVA Therapy / adverse effects*
Parity
Pregnancy
Prenatal Exposure Delayed Effects
Smoking / adverse effects
Comments/Corrections
Comment In:
Arch Dermatol. 1995 Apr;131(4):492-3   [PMID:  7726600 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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