| Psoralen photochemotherapy (PUVA) and pregnancy. | |
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MedLine Citation:
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PMID: 7772086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND DESIGN: Psoralen photochemotherapy (PUVA) may carry a risk of mutagenesis and teratogenesis. Using a medical birth registry and other health registries, infants born to women who had been treated with PUVA were identified. Exposure information was obtained from treating hospitals and from the license-granting agency. A total of 504 infants were born of pregnancies occurring after PUVA treatment, and 689 infants were born of pregnancies occurring before such treatment. In another 14 cases, treatment occurred during pregnancy. RESULTS: No increase in infant or child mortality or in the presence of congenital malformations could be seen after PUVA treatment. There was a marked increase in low-birth-weight infants when pregnancy occurred after treatment, and this is probably not explained by maternal smoking, but could be an effect of the underlying disease. CONCLUSIONS: The theoretical mutagenic and teratogenic effect of PUVA treatment apparently does not carry any significant risk for abnormal delivery outcome. |
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Authors:
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J G Gunnarskog; A J K?ll?n; B G Lindel?f; B Sigurgeirsson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 129 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-04-02 Completed Date: 1993-04-02 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 320-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology, National Board of Health, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
/
epidemiology*,
etiology Adult Birth Weight Female Fetal Death Humans Infant, Newborn Male Maternal Age PUVA Therapy / adverse effects* Parity Pregnancy Prenatal Exposure Delayed Effects Smoking / adverse effects |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 1995 Apr;131(4):492-3
[PMID:
7726600
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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