Document Detail

Psoralen photochemotherapy (PUVA) and pregnancy.
MedLine Citation:
PMID:  7772086     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND DESIGN: Psoralen photochemotherapy (PUVA) may carry a risk of mutagenesis and teratogenesis. Using a medical birth registry and other health registries, infants born to women who had been treated with PUVA were identified. Exposure information was obtained from treating hospitals and from the license-granting agency. A total of 504 infants were born of pregnancies occurring after PUVA treatment, and 689 infants were born of pregnancies occurring before such treatment. In another 14 cases, treatment occurred during pregnancy. RESULTS: No increase in infant or child mortality or in the presence of congenital malformations could be seen after PUVA treatment. There was a marked increase in low-birth-weight infants when pregnancy occurred after treatment, and this is probably not explained by maternal smoking, but could be an effect of the underlying disease. CONCLUSIONS: The theoretical mutagenic and teratogenic effect of PUVA treatment apparently does not carry any significant risk for abnormal delivery outcome.
J G Gunnarskog; A J K?ll?n; B G Lindel?f; B Sigurgeirsson
Related Documents :
11845946 - Efficacy and tolerance of adapalene cream 0.1% compared with its cream vehicle for the ...
6447576 - Nonsteroidal topical treatment of inflammatory dermatoses.
1218306 - A table for the rapid determination of ret and tdf values.
12961096 - Imperforate anus with rectopenile fistula.
1595626 - Measured vs calculated plasma osmolality in infants with very low birth weights.
21447596 - Plasma ip-10 as a predictor of serious bacterial infection in infants less than 4 month...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  129     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  320-3     Citation Subset:  AIM; IM    
Department of Epidemiology, National Board of Health, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / epidemiology*,  etiology
Birth Weight
Fetal Death
Infant, Newborn
Maternal Age
PUVA Therapy / adverse effects*
Prenatal Exposure Delayed Effects
Smoking / adverse effects
Comment In:
Arch Dermatol. 1995 Apr;131(4):492-3   [PMID:  7726600 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rapid development of umbilical metastases after laparoscopic cholecystectomy for unsuspected gallbla...
Next Document:  Complications following axillary dissection for breast carcinoma