Document Detail

Psoralen-DNA photoreaction: controlled production of mono- and diadducts with nanosecond ultraviolet laser pulses.
MedLine Citation:
PMID:  887929     Owner:  NLM     Status:  MEDLINE    
Samples of DNA which contain adducts of a new psoralen derivative, but no cross-links, have been prepared by irradiating mixtures of DNA and the derivative with single, 15-nanosecond pulses of laser light. Succeeding pulses introduce cross-links. The ability to rapidly and selectively create monoadducts and corss-links may allow the use of psoralens as probes of dynamic processes in living cells.
B H Johnston; M A Johnson; C B Moore; J E Hearst
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  197     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  906-8     Citation Subset:  IM    
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MeSH Terms
Coumarins* / analogs & derivatives
DNA, Single-Stranded
DNA, Viral*
Ultraviolet Rays
Reg. No./Substance:
0/Coumarins; 0/DNA, Single-Stranded; 0/DNA, Viral; 0/Psoralens; 66-97-7/Ficusin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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