| Pseudoxanthoma-elasticum-like skin changes induced by penicillamine. | |
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MedLine Citation:
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PMID: 1558988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. These changes are seen primarily in patients with Wilson's disease or cystinuria who are on long-term therapy. This is a report of a patient with cystinuria on long-term, high-dose penicillamine who developed pseudoxanthoma-elasticum-like lesions. Coalescent yellow papules with a 'plucked-chicken skin' appearance were seen in the axillae and on the neck while redundant skin folds were noted in the anterior axillary line and lower buttocks. By light and electron microscopy, involved and uninvolved skin demonstrated 'lumpy-bumpy' dermal elastic fibers with no calcium deposition. These histologic changes are similar to those previously described in patients with penicillamine-induced skin lesions. |
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Authors:
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J L Bolognia; I Braverman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 184 ISSN: 1018-8665 ISO Abbreviation: Dermatology (Basel) Publication Date: 1992 |
Date Detail:
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Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 12-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Collagen / drug effects Elastin / drug effects Humans Male Microscopy, Electron Penicillamine / adverse effects* Pseudoxanthoma Elasticum / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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52-67-5/Penicillamine; 9007-34-5/Collagen; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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