Document Detail

Pseudoxanthoma-elasticum-like skin changes induced by penicillamine.
MedLine Citation:
PMID:  1558988     Owner:  NLM     Status:  MEDLINE    
The interference of penicillamine with collagen and elastin cross-linking can lead to wrinkling and anetoderma-like lesions in flexural areas as well as fragility and hemorrhagic blisters in pressure areas. These changes are seen primarily in patients with Wilson's disease or cystinuria who are on long-term therapy. This is a report of a patient with cystinuria on long-term, high-dose penicillamine who developed pseudoxanthoma-elasticum-like lesions. Coalescent yellow papules with a 'plucked-chicken skin' appearance were seen in the axillae and on the neck while redundant skin folds were noted in the anterior axillary line and lower buttocks. By light and electron microscopy, involved and uninvolved skin demonstrated 'lumpy-bumpy' dermal elastic fibers with no calcium deposition. These histologic changes are similar to those previously described in patients with penicillamine-induced skin lesions.
J L Bolognia; I Braverman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  184     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1992  
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  12-8     Citation Subset:  IM    
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510.
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MeSH Terms
Collagen / drug effects
Elastin / drug effects
Microscopy, Electron
Penicillamine / adverse effects*
Pseudoxanthoma Elasticum / chemically induced*,  pathology
Reg. No./Substance:
52-67-5/Penicillamine; 9007-34-5/Collagen; 9007-58-3/Elastin

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